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Pregnancy-Associated Breast Cancer: A Diagnostic and Therapeutic Challenge

Pregnancy-associated breast cancer (PABC) is commonly defined as a breast cancer occurring during pregnancy, throughout 1 year postpartum, or during lactation. Despite being a rare circumstance, PABC is one of the most common types of malignancies occurring during pregnancy and lactation, with growi...

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Autores principales: Galati, Francesca, Magri, Valentina, Arias-Cadena, Paula Andrea, Moffa, Giuliana, Rizzo, Veronica, Pasculli, Marcella, Botticelli, Andrea, Pediconi, Federica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955856/
https://www.ncbi.nlm.nih.gov/pubmed/36832092
http://dx.doi.org/10.3390/diagnostics13040604
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author Galati, Francesca
Magri, Valentina
Arias-Cadena, Paula Andrea
Moffa, Giuliana
Rizzo, Veronica
Pasculli, Marcella
Botticelli, Andrea
Pediconi, Federica
author_facet Galati, Francesca
Magri, Valentina
Arias-Cadena, Paula Andrea
Moffa, Giuliana
Rizzo, Veronica
Pasculli, Marcella
Botticelli, Andrea
Pediconi, Federica
author_sort Galati, Francesca
collection PubMed
description Pregnancy-associated breast cancer (PABC) is commonly defined as a breast cancer occurring during pregnancy, throughout 1 year postpartum, or during lactation. Despite being a rare circumstance, PABC is one of the most common types of malignancies occurring during pregnancy and lactation, with growing incidence in developed countries, due both to decreasing age at onset of breast cancer and to increasing maternal age. Diagnosis and management of malignancy in the prenatal and postnatal settings are challenging for practitioners, as the structural and functional changes that the breast undergoes may be misleading for both the radiologist and the clinician. Furthermore, safety concerns for the mother and child, as well as psychological aspects in this unique and delicate condition, need to be constantly considered. In this comprehensive review, clinical, diagnostic, and therapeutic aspects of PABC (including surgery, chemotherapy and other systemic treatments, and radiotherapy) are presented and fully discussed, based on medical literature, current international clinical guidelines, and systematic practice.
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spelling pubmed-99558562023-02-25 Pregnancy-Associated Breast Cancer: A Diagnostic and Therapeutic Challenge Galati, Francesca Magri, Valentina Arias-Cadena, Paula Andrea Moffa, Giuliana Rizzo, Veronica Pasculli, Marcella Botticelli, Andrea Pediconi, Federica Diagnostics (Basel) Review Pregnancy-associated breast cancer (PABC) is commonly defined as a breast cancer occurring during pregnancy, throughout 1 year postpartum, or during lactation. Despite being a rare circumstance, PABC is one of the most common types of malignancies occurring during pregnancy and lactation, with growing incidence in developed countries, due both to decreasing age at onset of breast cancer and to increasing maternal age. Diagnosis and management of malignancy in the prenatal and postnatal settings are challenging for practitioners, as the structural and functional changes that the breast undergoes may be misleading for both the radiologist and the clinician. Furthermore, safety concerns for the mother and child, as well as psychological aspects in this unique and delicate condition, need to be constantly considered. In this comprehensive review, clinical, diagnostic, and therapeutic aspects of PABC (including surgery, chemotherapy and other systemic treatments, and radiotherapy) are presented and fully discussed, based on medical literature, current international clinical guidelines, and systematic practice. MDPI 2023-02-07 /pmc/articles/PMC9955856/ /pubmed/36832092 http://dx.doi.org/10.3390/diagnostics13040604 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Galati, Francesca
Magri, Valentina
Arias-Cadena, Paula Andrea
Moffa, Giuliana
Rizzo, Veronica
Pasculli, Marcella
Botticelli, Andrea
Pediconi, Federica
Pregnancy-Associated Breast Cancer: A Diagnostic and Therapeutic Challenge
title Pregnancy-Associated Breast Cancer: A Diagnostic and Therapeutic Challenge
title_full Pregnancy-Associated Breast Cancer: A Diagnostic and Therapeutic Challenge
title_fullStr Pregnancy-Associated Breast Cancer: A Diagnostic and Therapeutic Challenge
title_full_unstemmed Pregnancy-Associated Breast Cancer: A Diagnostic and Therapeutic Challenge
title_short Pregnancy-Associated Breast Cancer: A Diagnostic and Therapeutic Challenge
title_sort pregnancy-associated breast cancer: a diagnostic and therapeutic challenge
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955856/
https://www.ncbi.nlm.nih.gov/pubmed/36832092
http://dx.doi.org/10.3390/diagnostics13040604
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