A microbiota and dietary metabolite integrates DNA repair and cell death to regulate embryo viability and aneuploidy during aging

During aging, environmental stressors and mutations along with reduced DNA repair cause germ cell aneuploidy and genome instability, which limits fertility and embryo development. Benevolent commensal microbiota and dietary plants secrete indoles, which improve healthspan and reproductive success, s...

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Detalles Bibliográficos
Autores principales: Sonowal, Robert, Swimm, Alyson I., Cingolani, Francesca, Parulekar, Noyonika, Cleverley, Tesia L., Sahoo, Anusmita, Ranawade, Ayush, Chaudhuri, Debalina, Mocarski, Edward S., Koehler, Heather, Nitsche, Karolina, Mesiano, Sam, Kalman, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9956122/
https://www.ncbi.nlm.nih.gov/pubmed/36827370
http://dx.doi.org/10.1126/sciadv.ade8653

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