Deregulated E2F Activity as a Cancer-Cell Specific Therapeutic Tool

The transcription factor E2F, the principal target of the tumor suppressor pRB, plays crucial roles in cell proliferation and tumor suppression. In almost all cancers, pRB function is disabled, and E2F activity is enhanced. To specifically target cancer cells, trials have been undertaken to suppress...

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Detalles Bibliográficos
Autores principales: Nakajima, Rinka, Zhao, Lin, Zhou, Yaxuan, Shirasawa, Mashiro, Uchida, Ayato, Murakawa, Hikaru, Fikriyanti, Mariana, Iwanaga, Ritsuko, Bradford, Andrew P., Araki, Keigo, Warita, Tomoko, Ohtani, Kiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9956157/
https://www.ncbi.nlm.nih.gov/pubmed/36833320
http://dx.doi.org/10.3390/genes14020393

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