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New Insights into the Genetics and Epigenetics of Aging Plasticity

Biological aging is characterized by irreversible cell cycle blockade, a decreased capacity for tissue regeneration, and an increased risk of age-related diseases and mortality. A variety of genetic and epigenetic factors regulate aging, including the abnormal expression of aging-related genes, incr...

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Detalles Bibliográficos
Autores principales: Zhang, Jie, Wang, Shixiao, Liu, Baohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9956228/
https://www.ncbi.nlm.nih.gov/pubmed/36833255
http://dx.doi.org/10.3390/genes14020329
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author Zhang, Jie
Wang, Shixiao
Liu, Baohua
author_facet Zhang, Jie
Wang, Shixiao
Liu, Baohua
author_sort Zhang, Jie
collection PubMed
description Biological aging is characterized by irreversible cell cycle blockade, a decreased capacity for tissue regeneration, and an increased risk of age-related diseases and mortality. A variety of genetic and epigenetic factors regulate aging, including the abnormal expression of aging-related genes, increased DNA methylation levels, altered histone modifications, and unbalanced protein translation homeostasis. The epitranscriptome is also closely associated with aging. Aging is regulated by both genetic and epigenetic factors, with significant variability, heterogeneity, and plasticity. Understanding the complex genetic and epigenetic mechanisms of aging will aid the identification of aging-related markers, which may in turn aid the development of effective interventions against this process. This review summarizes the latest research in the field of aging from a genetic and epigenetic perspective. We analyze the relationships between aging-related genes, examine the possibility of reversing the aging process by altering epigenetic age.
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spelling pubmed-99562282023-02-25 New Insights into the Genetics and Epigenetics of Aging Plasticity Zhang, Jie Wang, Shixiao Liu, Baohua Genes (Basel) Review Biological aging is characterized by irreversible cell cycle blockade, a decreased capacity for tissue regeneration, and an increased risk of age-related diseases and mortality. A variety of genetic and epigenetic factors regulate aging, including the abnormal expression of aging-related genes, increased DNA methylation levels, altered histone modifications, and unbalanced protein translation homeostasis. The epitranscriptome is also closely associated with aging. Aging is regulated by both genetic and epigenetic factors, with significant variability, heterogeneity, and plasticity. Understanding the complex genetic and epigenetic mechanisms of aging will aid the identification of aging-related markers, which may in turn aid the development of effective interventions against this process. This review summarizes the latest research in the field of aging from a genetic and epigenetic perspective. We analyze the relationships between aging-related genes, examine the possibility of reversing the aging process by altering epigenetic age. MDPI 2023-01-27 /pmc/articles/PMC9956228/ /pubmed/36833255 http://dx.doi.org/10.3390/genes14020329 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhang, Jie
Wang, Shixiao
Liu, Baohua
New Insights into the Genetics and Epigenetics of Aging Plasticity
title New Insights into the Genetics and Epigenetics of Aging Plasticity
title_full New Insights into the Genetics and Epigenetics of Aging Plasticity
title_fullStr New Insights into the Genetics and Epigenetics of Aging Plasticity
title_full_unstemmed New Insights into the Genetics and Epigenetics of Aging Plasticity
title_short New Insights into the Genetics and Epigenetics of Aging Plasticity
title_sort new insights into the genetics and epigenetics of aging plasticity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9956228/
https://www.ncbi.nlm.nih.gov/pubmed/36833255
http://dx.doi.org/10.3390/genes14020329
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