Cargando…

TCF7L1 Regulates LGR5 Expression in Colorectal Cancer Cells

Mutations in components of the Wnt/β-catenin signaling pathway drive colorectal cancer (CRC), in part, by deregulating expression of genes controlled by the T-cell factor (TCF) family of transcription factors. TCFs contain a conserved DNA binding domain that mediates association with TCF binding ele...

Descripción completa

Detalles Bibliográficos
Autores principales:	King, Carli M., Marx, Olivia M., Ding, Wei, Koltun, Walter A., Yochum, Gregory S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9956233/ https://www.ncbi.nlm.nih.gov/pubmed/36833408 http://dx.doi.org/10.3390/genes14020481

Ejemplares similares

Transcriptome Analyses Identify Deregulated MYC in Early Onset Colorectal Cancer
por: Marx, Olivia M., et al.
Publicado: (2022)

LGR6 activates the Wnt/β-catenin signaling pathway and forms a β-catenin/TCF7L2/LGR6 feedback loop in LGR6(high) cervical cancer stem cells
por: Feng, Qian, et al.
Publicado: (2021)

Molecular genetics of early-onset colorectal cancer
por: Marx, Olivia, et al.
Publicado: (2023)

The Crohn’s disease associated SNP rs6651252 impacts MYC gene expression in human colonic epithelial cells
por: Matthews, Stephen M., et al.
Publicado: (2019)

LGR5 expression is regulated by EGF in early colorectal adenomas and governs EGFR inhibitor sensitivity
por: Morgan, R G, et al.
Publicado: (2018)

Transcriptome profiling of LGR5 positive colorectal cancer cells
por: Hirsch, Daniela, et al.
Publicado: (2014)

Characterization of LGR5 stem cells in colorectal adenomas and carcinomas
por: Baker, Ann-Marie, et al.
Publicado: (2015)

LGR4 and LGR5 Regulate Hair Cell Differentiation in the Sensory Epithelium of the Developing Mouse Cochlea
por: Żak, Magdalena, et al.
Publicado: (2016)

LGR5 and LGR6 in stem cell biology and ovarian cancer
por: Schindler, Adam J., et al.
Publicado: (2017)

LGR4 and LGR5 Function Redundantly During Human Endoderm Differentiation
por: Tsai, Yu-Hwai, et al.
Publicado: (2016)

Co-expression of Lgr5 and CXCR4 characterizes cancer stem-like cells of colorectal cancer
por: Wu, Weidong, et al.
Publicado: (2016)

Prognostic Value of LGR5 in Colorectal Cancer: A Meta-Analysis
por: Chen, Qing, et al.
Publicado: (2014)

Targeting LGR5 in Colorectal Cancer: therapeutic gold or too plastic?
por: Morgan, RG, et al.
Publicado: (2018)

Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer
por: Fumagalli, Arianna, et al.
Publicado: (2020)

Limited TCF7L2 Expression in MS Lesions
por: Lürbke, Alexander, et al.
Publicado: (2013)

Cytoplasmic expression of LGR5 in pancreatic adenocarcinoma
por: Mizuno, Nobumasa, et al.
Publicado: (2013)

Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6
por: Lee, Joo-Hyeon, et al.
Publicado: (2017)

Characterization of the Transcriptomes of Lgr5+ Hair Cell Progenitors and Lgr5- Supporting Cells in the Mouse Cochlea
por: Cheng, Cheng, et al.
Publicado: (2017)

Expression and functional regulation of stemness gene Lgr5 in esophageal squamous cell carcinoma
por: Lv, Zhuan, et al.
Publicado: (2017)

TCF7L2 is a master regulator of insulin production and processing
por: Zhou, Yuedan, et al.
Publicado: (2014)

Cofilin 1 promotes bladder cancer and is regulated by TCF7L2
por: Wang, Fei, et al.
Publicado: (2017)

Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway
por: Pathak, Trayambak, et al.
Publicado: (2023)

Characterization of LGR5 expression in poorly differentiated colorectal carcinoma with mismatch repair protein deficiency
por: Nakajima, Tomoyuki, et al.
Publicado: (2020)

Reduced total serum bilirubin levels are associated with ulcerative colitis
por: Schieffer, Kathleen M., et al.
Publicado: (2017)

Modulation of Tcf7l2 Expression Alters Behavior in Mice
por: Savic, Daniel, et al.
Publicado: (2011)

Assessment of TCF7L2 expression after bariatric surgery
por: Macedo, Carlos Eduardo S., et al.
Publicado: (2019)

Lgr5 in cancer biology: functional identification of Lgr5 in cancer progression and potential opportunities for novel therapy
por: Xu, Liangliang, et al.
Publicado: (2019)

R-Spondin Potentiates Wnt/β-Catenin Signaling through Orphan Receptors LGR4 and LGR5
por: Ruffner, Heinz, et al.
Publicado: (2012)

Dickkopf-2 regulates the stem cell marker LGR5 in colorectal cancer via HNF4α1
por: Shin, Jae Hun, et al.
Publicado: (2021)

Tcf7l1 directly regulates cardiomyocyte differentiation in embryonic stem cells
por: Liang, Rui, et al.
Publicado: (2018)

TCF7L2 regulates postmitotic differentiation programmes and excitability patterns in the thalamus
por: Lipiec, Marcin Andrzej, et al.
Publicado: (2020)

TCF7L1 regulates cytokine response and neuroendocrine differentiation of prostate cancer
por: Wen, Yu-Ching, et al.
Publicado: (2021)

Lgr5 Methylation in Cancer Stem Cell Differentiation and Prognosis-Prediction in Colorectal Cancer
por: Su, Shasha, et al.
Publicado: (2015)

Full-length LGR5-positive cells have chemoresistant characteristics in colorectal cancer
por: Osawa, Hideki, et al.
Publicado: (2016)

TCF7L1 Modulates Colorectal Cancer Growth by Inhibiting Expression of the Tumor-Suppressor Gene EPHB3
por: Murphy, Matthew, et al.
Publicado: (2016)

Nuclear expression of TCF4/TCF7L2 is correlated with poor prognosis in patients with esophageal squamous cell carcinoma
por: Ishiguro, Hideyuki, et al.
Publicado: (2016)

LGR5 is associated with tumor aggressiveness in papillary thyroid cancer
por: Michelotti, Gregory, et al.
Publicado: (2015)

LGR5 Is a Negative Regulator of Tumourigenicity, Antagonizes Wnt Signalling and Regulates Cell Adhesion in Colorectal Cancer Cell Lines
por: Walker, Francesca, et al.
Publicado: (2011)

Heterogeneous expression of Lgr5 as a risk factor for focal invasion and distant metastasis of colorectal carcinoma
por: Zheng, Zhong, et al.
Publicado: (2018)

The TCF7L2 locus and type 1 diabetes
por: Qu, Hui-Qi, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_don3hpmruvtvalsg6tgd247n82