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Exploiting Autophagy-Dependent Neoantigen Presentation in Tumor Microenvironment

Autophagy constitutes a well-known homeostatic and catabolic process that is responsible for degradation and recycling of cellular components. It is a key regulatory mechanism for several cellular functions, whereas its dysregulation is associated with tumorigenesis, tumor–stroma interactions and re...

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Autores principales: Koustas, Evangelos, Trifylli, Eleni-Myrto, Sarantis, Panagiotis, Papadopoulos, Nikolaos, Papanikolopoulos, Konstantinos, Aloizos, Georgios, Damaskos, Christos, Garmpis, Nikolaos, Garmpi, Anna, Matthaios, Dimitris, Karamouzis, Michalis V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9956312/
https://www.ncbi.nlm.nih.gov/pubmed/36833401
http://dx.doi.org/10.3390/genes14020474
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author Koustas, Evangelos
Trifylli, Eleni-Myrto
Sarantis, Panagiotis
Papadopoulos, Nikolaos
Papanikolopoulos, Konstantinos
Aloizos, Georgios
Damaskos, Christos
Garmpis, Nikolaos
Garmpi, Anna
Matthaios, Dimitris
Karamouzis, Michalis V.
author_facet Koustas, Evangelos
Trifylli, Eleni-Myrto
Sarantis, Panagiotis
Papadopoulos, Nikolaos
Papanikolopoulos, Konstantinos
Aloizos, Georgios
Damaskos, Christos
Garmpis, Nikolaos
Garmpi, Anna
Matthaios, Dimitris
Karamouzis, Michalis V.
author_sort Koustas, Evangelos
collection PubMed
description Autophagy constitutes a well-known homeostatic and catabolic process that is responsible for degradation and recycling of cellular components. It is a key regulatory mechanism for several cellular functions, whereas its dysregulation is associated with tumorigenesis, tumor–stroma interactions and resistance to cancer therapy. A growing body of evidence has proven that autophagy affects the tumor microenvironment, while it is also considered a key factor for function of several immune cells, such as APCs, T-cells, and macrophages. Moreover, it is implicated in presentation of neo-antigens of tumor cells in both MHC-I and MHC-II in dendritic cells (DCs) in functional activity of immune cells by creating T-cell memory, as well as in cross-presentation of neo-antigens for MHC-I presentation and the internalization process. Currently, autophagy has a crucial role in immunotherapy. Emergence of cancer immunotherapy has already shown some remarkable results, having changed therapeutic strategy in clinical practice for several cancer types. Despite these promising long-term responses, several patients seem to lack the ability to respond to immune checkpoint inhibitors. Thus, autophagy through neo-antigen presentation is a potential target in order to strengthen or attenuate the effects of immunotherapy against different types of cancer. This review will shed light on the recent advances and future directions of autophagy-dependent neo-antigen presentation and consequently its role in immunotherapy for malignant tumors.
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spelling pubmed-99563122023-02-25 Exploiting Autophagy-Dependent Neoantigen Presentation in Tumor Microenvironment Koustas, Evangelos Trifylli, Eleni-Myrto Sarantis, Panagiotis Papadopoulos, Nikolaos Papanikolopoulos, Konstantinos Aloizos, Georgios Damaskos, Christos Garmpis, Nikolaos Garmpi, Anna Matthaios, Dimitris Karamouzis, Michalis V. Genes (Basel) Review Autophagy constitutes a well-known homeostatic and catabolic process that is responsible for degradation and recycling of cellular components. It is a key regulatory mechanism for several cellular functions, whereas its dysregulation is associated with tumorigenesis, tumor–stroma interactions and resistance to cancer therapy. A growing body of evidence has proven that autophagy affects the tumor microenvironment, while it is also considered a key factor for function of several immune cells, such as APCs, T-cells, and macrophages. Moreover, it is implicated in presentation of neo-antigens of tumor cells in both MHC-I and MHC-II in dendritic cells (DCs) in functional activity of immune cells by creating T-cell memory, as well as in cross-presentation of neo-antigens for MHC-I presentation and the internalization process. Currently, autophagy has a crucial role in immunotherapy. Emergence of cancer immunotherapy has already shown some remarkable results, having changed therapeutic strategy in clinical practice for several cancer types. Despite these promising long-term responses, several patients seem to lack the ability to respond to immune checkpoint inhibitors. Thus, autophagy through neo-antigen presentation is a potential target in order to strengthen or attenuate the effects of immunotherapy against different types of cancer. This review will shed light on the recent advances and future directions of autophagy-dependent neo-antigen presentation and consequently its role in immunotherapy for malignant tumors. MDPI 2023-02-13 /pmc/articles/PMC9956312/ /pubmed/36833401 http://dx.doi.org/10.3390/genes14020474 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Koustas, Evangelos
Trifylli, Eleni-Myrto
Sarantis, Panagiotis
Papadopoulos, Nikolaos
Papanikolopoulos, Konstantinos
Aloizos, Georgios
Damaskos, Christos
Garmpis, Nikolaos
Garmpi, Anna
Matthaios, Dimitris
Karamouzis, Michalis V.
Exploiting Autophagy-Dependent Neoantigen Presentation in Tumor Microenvironment
title Exploiting Autophagy-Dependent Neoantigen Presentation in Tumor Microenvironment
title_full Exploiting Autophagy-Dependent Neoantigen Presentation in Tumor Microenvironment
title_fullStr Exploiting Autophagy-Dependent Neoantigen Presentation in Tumor Microenvironment
title_full_unstemmed Exploiting Autophagy-Dependent Neoantigen Presentation in Tumor Microenvironment
title_short Exploiting Autophagy-Dependent Neoantigen Presentation in Tumor Microenvironment
title_sort exploiting autophagy-dependent neoantigen presentation in tumor microenvironment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9956312/
https://www.ncbi.nlm.nih.gov/pubmed/36833401
http://dx.doi.org/10.3390/genes14020474
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