Cargando…
Synthesis and Degradation Properties of Sericin/PVA Hydrogels
One method of treating diabetic foot ulcers, mainly superficial and deep ulcers, is using a wound dressing in the form of a hydrogel. Sericin derived from silkworm cocoons is a promising hydrogel material candidate because it has anti-inflammatory properties and stimulates collagen production. Seric...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9956334/ https://www.ncbi.nlm.nih.gov/pubmed/36826246 http://dx.doi.org/10.3390/gels9020076 |
_version_ | 1784894567104905216 |
---|---|
author | Ekasurya, William Sebastian, Joses Puspitasari, Dita Asri, Putri P. P. Asri, Lia A. T. W. |
author_facet | Ekasurya, William Sebastian, Joses Puspitasari, Dita Asri, Putri P. P. Asri, Lia A. T. W. |
author_sort | Ekasurya, William |
collection | PubMed |
description | One method of treating diabetic foot ulcers, mainly superficial and deep ulcers, is using a wound dressing in the form of a hydrogel. Sericin derived from silkworm cocoons is a promising hydrogel material candidate because it has anti-inflammatory properties and stimulates collagen production. Sericin was combined with PVA to increase the stability of the resulting hydrogel. Sericin/PVA hydrogel was prepared using the freeze–thawing method with variations in the solution concentration and volume ratio of PVA and sericin. Sericin was successfully extracted using an autoclave method. The FTIR results confirmed that sericin extracted from the cocoon had a dominant secondary structure in the form of a β-sheet. Hydrogel with a concentration of 4% with a 1:1 ratio of PVA and sericin showed good stability and resulted in a hydrogel with characteristics that combine PVA and sericin. The resulting hydrogel had an average pore size range of 24–191 µm and a porosity range of 70–85%, which meets the requirements for wound dressings. Through degradation testing in PBS solution, it was found that the sericin/PVA hydrogel experienced degradation of 60–75% after 672 h of testing. |
format | Online Article Text |
id | pubmed-9956334 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99563342023-02-25 Synthesis and Degradation Properties of Sericin/PVA Hydrogels Ekasurya, William Sebastian, Joses Puspitasari, Dita Asri, Putri P. P. Asri, Lia A. T. W. Gels Article One method of treating diabetic foot ulcers, mainly superficial and deep ulcers, is using a wound dressing in the form of a hydrogel. Sericin derived from silkworm cocoons is a promising hydrogel material candidate because it has anti-inflammatory properties and stimulates collagen production. Sericin was combined with PVA to increase the stability of the resulting hydrogel. Sericin/PVA hydrogel was prepared using the freeze–thawing method with variations in the solution concentration and volume ratio of PVA and sericin. Sericin was successfully extracted using an autoclave method. The FTIR results confirmed that sericin extracted from the cocoon had a dominant secondary structure in the form of a β-sheet. Hydrogel with a concentration of 4% with a 1:1 ratio of PVA and sericin showed good stability and resulted in a hydrogel with characteristics that combine PVA and sericin. The resulting hydrogel had an average pore size range of 24–191 µm and a porosity range of 70–85%, which meets the requirements for wound dressings. Through degradation testing in PBS solution, it was found that the sericin/PVA hydrogel experienced degradation of 60–75% after 672 h of testing. MDPI 2023-01-17 /pmc/articles/PMC9956334/ /pubmed/36826246 http://dx.doi.org/10.3390/gels9020076 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ekasurya, William Sebastian, Joses Puspitasari, Dita Asri, Putri P. P. Asri, Lia A. T. W. Synthesis and Degradation Properties of Sericin/PVA Hydrogels |
title | Synthesis and Degradation Properties of Sericin/PVA Hydrogels |
title_full | Synthesis and Degradation Properties of Sericin/PVA Hydrogels |
title_fullStr | Synthesis and Degradation Properties of Sericin/PVA Hydrogels |
title_full_unstemmed | Synthesis and Degradation Properties of Sericin/PVA Hydrogels |
title_short | Synthesis and Degradation Properties of Sericin/PVA Hydrogels |
title_sort | synthesis and degradation properties of sericin/pva hydrogels |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9956334/ https://www.ncbi.nlm.nih.gov/pubmed/36826246 http://dx.doi.org/10.3390/gels9020076 |
work_keys_str_mv | AT ekasuryawilliam synthesisanddegradationpropertiesofsericinpvahydrogels AT sebastianjoses synthesisanddegradationpropertiesofsericinpvahydrogels AT puspitasaridita synthesisanddegradationpropertiesofsericinpvahydrogels AT asriputripp synthesisanddegradationpropertiesofsericinpvahydrogels AT asriliaatw synthesisanddegradationpropertiesofsericinpvahydrogels |