Cargando…

Synthesis and Degradation Properties of Sericin/PVA Hydrogels

One method of treating diabetic foot ulcers, mainly superficial and deep ulcers, is using a wound dressing in the form of a hydrogel. Sericin derived from silkworm cocoons is a promising hydrogel material candidate because it has anti-inflammatory properties and stimulates collagen production. Seric...

Descripción completa

Detalles Bibliográficos
Autores principales: Ekasurya, William, Sebastian, Joses, Puspitasari, Dita, Asri, Putri P. P., Asri, Lia A. T. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9956334/
https://www.ncbi.nlm.nih.gov/pubmed/36826246
http://dx.doi.org/10.3390/gels9020076
_version_ 1784894567104905216
author Ekasurya, William
Sebastian, Joses
Puspitasari, Dita
Asri, Putri P. P.
Asri, Lia A. T. W.
author_facet Ekasurya, William
Sebastian, Joses
Puspitasari, Dita
Asri, Putri P. P.
Asri, Lia A. T. W.
author_sort Ekasurya, William
collection PubMed
description One method of treating diabetic foot ulcers, mainly superficial and deep ulcers, is using a wound dressing in the form of a hydrogel. Sericin derived from silkworm cocoons is a promising hydrogel material candidate because it has anti-inflammatory properties and stimulates collagen production. Sericin was combined with PVA to increase the stability of the resulting hydrogel. Sericin/PVA hydrogel was prepared using the freeze–thawing method with variations in the solution concentration and volume ratio of PVA and sericin. Sericin was successfully extracted using an autoclave method. The FTIR results confirmed that sericin extracted from the cocoon had a dominant secondary structure in the form of a β-sheet. Hydrogel with a concentration of 4% with a 1:1 ratio of PVA and sericin showed good stability and resulted in a hydrogel with characteristics that combine PVA and sericin. The resulting hydrogel had an average pore size range of 24–191 µm and a porosity range of 70–85%, which meets the requirements for wound dressings. Through degradation testing in PBS solution, it was found that the sericin/PVA hydrogel experienced degradation of 60–75% after 672 h of testing.
format Online
Article
Text
id pubmed-9956334
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-99563342023-02-25 Synthesis and Degradation Properties of Sericin/PVA Hydrogels Ekasurya, William Sebastian, Joses Puspitasari, Dita Asri, Putri P. P. Asri, Lia A. T. W. Gels Article One method of treating diabetic foot ulcers, mainly superficial and deep ulcers, is using a wound dressing in the form of a hydrogel. Sericin derived from silkworm cocoons is a promising hydrogel material candidate because it has anti-inflammatory properties and stimulates collagen production. Sericin was combined with PVA to increase the stability of the resulting hydrogel. Sericin/PVA hydrogel was prepared using the freeze–thawing method with variations in the solution concentration and volume ratio of PVA and sericin. Sericin was successfully extracted using an autoclave method. The FTIR results confirmed that sericin extracted from the cocoon had a dominant secondary structure in the form of a β-sheet. Hydrogel with a concentration of 4% with a 1:1 ratio of PVA and sericin showed good stability and resulted in a hydrogel with characteristics that combine PVA and sericin. The resulting hydrogel had an average pore size range of 24–191 µm and a porosity range of 70–85%, which meets the requirements for wound dressings. Through degradation testing in PBS solution, it was found that the sericin/PVA hydrogel experienced degradation of 60–75% after 672 h of testing. MDPI 2023-01-17 /pmc/articles/PMC9956334/ /pubmed/36826246 http://dx.doi.org/10.3390/gels9020076 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ekasurya, William
Sebastian, Joses
Puspitasari, Dita
Asri, Putri P. P.
Asri, Lia A. T. W.
Synthesis and Degradation Properties of Sericin/PVA Hydrogels
title Synthesis and Degradation Properties of Sericin/PVA Hydrogels
title_full Synthesis and Degradation Properties of Sericin/PVA Hydrogels
title_fullStr Synthesis and Degradation Properties of Sericin/PVA Hydrogels
title_full_unstemmed Synthesis and Degradation Properties of Sericin/PVA Hydrogels
title_short Synthesis and Degradation Properties of Sericin/PVA Hydrogels
title_sort synthesis and degradation properties of sericin/pva hydrogels
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9956334/
https://www.ncbi.nlm.nih.gov/pubmed/36826246
http://dx.doi.org/10.3390/gels9020076
work_keys_str_mv AT ekasuryawilliam synthesisanddegradationpropertiesofsericinpvahydrogels
AT sebastianjoses synthesisanddegradationpropertiesofsericinpvahydrogels
AT puspitasaridita synthesisanddegradationpropertiesofsericinpvahydrogels
AT asriputripp synthesisanddegradationpropertiesofsericinpvahydrogels
AT asriliaatw synthesisanddegradationpropertiesofsericinpvahydrogels