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Role of miR-143 and miR-146 in Risk Evaluation of Coronary Artery Diseases in Autopsied Samples

Coronary artery disease (CAD) is a common and fatal cardiovascular disease. Among known CAD risk factors, miRNA polymorphisms, such as Has-miR-143 (rs41291957 C>G) and Has-miR-146a (rs2910164 G>A), have emerged as important genetic markers of CAD. Despite many genetic association studies in mu...

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Autores principales: Tie, Jian, Takanari, Hiroki, Ota, Koya, Okuda, Takahisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9956587/
https://www.ncbi.nlm.nih.gov/pubmed/36833398
http://dx.doi.org/10.3390/genes14020471
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author Tie, Jian
Takanari, Hiroki
Ota, Koya
Okuda, Takahisa
author_facet Tie, Jian
Takanari, Hiroki
Ota, Koya
Okuda, Takahisa
author_sort Tie, Jian
collection PubMed
description Coronary artery disease (CAD) is a common and fatal cardiovascular disease. Among known CAD risk factors, miRNA polymorphisms, such as Has-miR-143 (rs41291957 C>G) and Has-miR-146a (rs2910164 G>A), have emerged as important genetic markers of CAD. Despite many genetic association studies in multiple populations, no study assessing the association between CAD risk and SNPs of miR-143 and miR-146 was documented in the Japanese people. Therefore, using the TaqMan SNP assay, we investigated two SNP genotypes in 151 subjects with forensic autopsy-proven CAD. After pathological observation, we used ImageJ software to assess the degree of coronary artery atresia. Moreover, the genotypes and miRNA content of the two groups of samples with atresia <10% and >10% were analyzed. The results showed that the CC genotype of rs2910164 was more frequent in patients with CAD than in controls, which was associated with the risk of CAD in the study population. However, Has-miR-143 rs41291957 genotype did not show a clear correlation with the risk of CAD.
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spelling pubmed-99565872023-02-25 Role of miR-143 and miR-146 in Risk Evaluation of Coronary Artery Diseases in Autopsied Samples Tie, Jian Takanari, Hiroki Ota, Koya Okuda, Takahisa Genes (Basel) Article Coronary artery disease (CAD) is a common and fatal cardiovascular disease. Among known CAD risk factors, miRNA polymorphisms, such as Has-miR-143 (rs41291957 C>G) and Has-miR-146a (rs2910164 G>A), have emerged as important genetic markers of CAD. Despite many genetic association studies in multiple populations, no study assessing the association between CAD risk and SNPs of miR-143 and miR-146 was documented in the Japanese people. Therefore, using the TaqMan SNP assay, we investigated two SNP genotypes in 151 subjects with forensic autopsy-proven CAD. After pathological observation, we used ImageJ software to assess the degree of coronary artery atresia. Moreover, the genotypes and miRNA content of the two groups of samples with atresia <10% and >10% were analyzed. The results showed that the CC genotype of rs2910164 was more frequent in patients with CAD than in controls, which was associated with the risk of CAD in the study population. However, Has-miR-143 rs41291957 genotype did not show a clear correlation with the risk of CAD. MDPI 2023-02-12 /pmc/articles/PMC9956587/ /pubmed/36833398 http://dx.doi.org/10.3390/genes14020471 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tie, Jian
Takanari, Hiroki
Ota, Koya
Okuda, Takahisa
Role of miR-143 and miR-146 in Risk Evaluation of Coronary Artery Diseases in Autopsied Samples
title Role of miR-143 and miR-146 in Risk Evaluation of Coronary Artery Diseases in Autopsied Samples
title_full Role of miR-143 and miR-146 in Risk Evaluation of Coronary Artery Diseases in Autopsied Samples
title_fullStr Role of miR-143 and miR-146 in Risk Evaluation of Coronary Artery Diseases in Autopsied Samples
title_full_unstemmed Role of miR-143 and miR-146 in Risk Evaluation of Coronary Artery Diseases in Autopsied Samples
title_short Role of miR-143 and miR-146 in Risk Evaluation of Coronary Artery Diseases in Autopsied Samples
title_sort role of mir-143 and mir-146 in risk evaluation of coronary artery diseases in autopsied samples
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9956587/
https://www.ncbi.nlm.nih.gov/pubmed/36833398
http://dx.doi.org/10.3390/genes14020471
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