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Role of miR-143 and miR-146 in Risk Evaluation of Coronary Artery Diseases in Autopsied Samples
Coronary artery disease (CAD) is a common and fatal cardiovascular disease. Among known CAD risk factors, miRNA polymorphisms, such as Has-miR-143 (rs41291957 C>G) and Has-miR-146a (rs2910164 G>A), have emerged as important genetic markers of CAD. Despite many genetic association studies in mu...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9956587/ https://www.ncbi.nlm.nih.gov/pubmed/36833398 http://dx.doi.org/10.3390/genes14020471 |
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author | Tie, Jian Takanari, Hiroki Ota, Koya Okuda, Takahisa |
author_facet | Tie, Jian Takanari, Hiroki Ota, Koya Okuda, Takahisa |
author_sort | Tie, Jian |
collection | PubMed |
description | Coronary artery disease (CAD) is a common and fatal cardiovascular disease. Among known CAD risk factors, miRNA polymorphisms, such as Has-miR-143 (rs41291957 C>G) and Has-miR-146a (rs2910164 G>A), have emerged as important genetic markers of CAD. Despite many genetic association studies in multiple populations, no study assessing the association between CAD risk and SNPs of miR-143 and miR-146 was documented in the Japanese people. Therefore, using the TaqMan SNP assay, we investigated two SNP genotypes in 151 subjects with forensic autopsy-proven CAD. After pathological observation, we used ImageJ software to assess the degree of coronary artery atresia. Moreover, the genotypes and miRNA content of the two groups of samples with atresia <10% and >10% were analyzed. The results showed that the CC genotype of rs2910164 was more frequent in patients with CAD than in controls, which was associated with the risk of CAD in the study population. However, Has-miR-143 rs41291957 genotype did not show a clear correlation with the risk of CAD. |
format | Online Article Text |
id | pubmed-9956587 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99565872023-02-25 Role of miR-143 and miR-146 in Risk Evaluation of Coronary Artery Diseases in Autopsied Samples Tie, Jian Takanari, Hiroki Ota, Koya Okuda, Takahisa Genes (Basel) Article Coronary artery disease (CAD) is a common and fatal cardiovascular disease. Among known CAD risk factors, miRNA polymorphisms, such as Has-miR-143 (rs41291957 C>G) and Has-miR-146a (rs2910164 G>A), have emerged as important genetic markers of CAD. Despite many genetic association studies in multiple populations, no study assessing the association between CAD risk and SNPs of miR-143 and miR-146 was documented in the Japanese people. Therefore, using the TaqMan SNP assay, we investigated two SNP genotypes in 151 subjects with forensic autopsy-proven CAD. After pathological observation, we used ImageJ software to assess the degree of coronary artery atresia. Moreover, the genotypes and miRNA content of the two groups of samples with atresia <10% and >10% were analyzed. The results showed that the CC genotype of rs2910164 was more frequent in patients with CAD than in controls, which was associated with the risk of CAD in the study population. However, Has-miR-143 rs41291957 genotype did not show a clear correlation with the risk of CAD. MDPI 2023-02-12 /pmc/articles/PMC9956587/ /pubmed/36833398 http://dx.doi.org/10.3390/genes14020471 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tie, Jian Takanari, Hiroki Ota, Koya Okuda, Takahisa Role of miR-143 and miR-146 in Risk Evaluation of Coronary Artery Diseases in Autopsied Samples |
title | Role of miR-143 and miR-146 in Risk Evaluation of Coronary Artery Diseases in Autopsied Samples |
title_full | Role of miR-143 and miR-146 in Risk Evaluation of Coronary Artery Diseases in Autopsied Samples |
title_fullStr | Role of miR-143 and miR-146 in Risk Evaluation of Coronary Artery Diseases in Autopsied Samples |
title_full_unstemmed | Role of miR-143 and miR-146 in Risk Evaluation of Coronary Artery Diseases in Autopsied Samples |
title_short | Role of miR-143 and miR-146 in Risk Evaluation of Coronary Artery Diseases in Autopsied Samples |
title_sort | role of mir-143 and mir-146 in risk evaluation of coronary artery diseases in autopsied samples |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9956587/ https://www.ncbi.nlm.nih.gov/pubmed/36833398 http://dx.doi.org/10.3390/genes14020471 |
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