The DNA binding domain and the C-terminal region of DNA Ligase IV specify its role in V(D)J recombination

DNA Ligase IV is responsible for the repair of DNA double-strand breaks (DSB), including DSBs that are generated during V(D)J recombination. Like other DNA ligases, Ligase IV contains a catalytic core with three subdomains—the DNA binding (DBD), the nucleotidyltransferase (NTD), and the oligonucleot...

Descripción completa

Detalles Bibliográficos
Autores principales: Malashetty, Vidyasagar, Au, Audrey, Chavez, Jose, Hanna, Mary, Chu, Jennifer, Penna, Jesse, Cortes, Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9956705/
https://www.ncbi.nlm.nih.gov/pubmed/36827388
http://dx.doi.org/10.1371/journal.pone.0282236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9956705/
https://www.ncbi.nlm.nih.gov/pubmed/36827388
http://dx.doi.org/10.1371/journal.pone.0282236

Ejemplares similares