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The DNA binding domain and the C-terminal region of DNA Ligase IV specify its role in V(D)J recombination

DNA Ligase IV is responsible for the repair of DNA double-strand breaks (DSB), including DSBs that are generated during V(D)J recombination. Like other DNA ligases, Ligase IV contains a catalytic core with three subdomains—the DNA binding (DBD), the nucleotidyltransferase (NTD), and the oligonucleot...

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Detalles Bibliográficos
Autores principales:	Malashetty, Vidyasagar, Au, Audrey, Chavez, Jose, Hanna, Mary, Chu, Jennifer, Penna, Jesse, Cortes, Patricia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9956705/ https://www.ncbi.nlm.nih.gov/pubmed/36827388 http://dx.doi.org/10.1371/journal.pone.0282236

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