Survival Disparities in US Black Compared to White Women with Hormone Receptor Positive-HER2 Negative Breast Cancer

Black women in the US have significantly higher breast cancer mortality than White women. Within biomarker-defined tumor subtypes, disparate outcomes seem to be limited to women with hormone receptor positive and HER2 negative (HR+/HER2−) breast cancer, a subtype usually associated with favorable pr...

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Detalles Bibliográficos
Autores principales: Lovejoy, Leann A., Shriver, Craig D., Haricharan, Svasti, Ellsworth, Rachel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9956998/
https://www.ncbi.nlm.nih.gov/pubmed/36833598
http://dx.doi.org/10.3390/ijerph20042903
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author Lovejoy, Leann A.
Shriver, Craig D.
Haricharan, Svasti
Ellsworth, Rachel E.
author_facet Lovejoy, Leann A.
Shriver, Craig D.
Haricharan, Svasti
Ellsworth, Rachel E.
author_sort Lovejoy, Leann A.
collection PubMed
description Black women in the US have significantly higher breast cancer mortality than White women. Within biomarker-defined tumor subtypes, disparate outcomes seem to be limited to women with hormone receptor positive and HER2 negative (HR+/HER2−) breast cancer, a subtype usually associated with favorable prognosis. In this review, we present data from an array of studies that demonstrate significantly higher mortality in Black compared to White women with HR+/HER2-breast cancer and contrast these data to studies from integrated healthcare systems that failed to find survival differences. Then, we describe factors, both biological and non-biological, that may contribute to disparate survival in Black women.
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spelling pubmed-99569982023-02-25 Survival Disparities in US Black Compared to White Women with Hormone Receptor Positive-HER2 Negative Breast Cancer Lovejoy, Leann A. Shriver, Craig D. Haricharan, Svasti Ellsworth, Rachel E. Int J Environ Res Public Health Review Black women in the US have significantly higher breast cancer mortality than White women. Within biomarker-defined tumor subtypes, disparate outcomes seem to be limited to women with hormone receptor positive and HER2 negative (HR+/HER2−) breast cancer, a subtype usually associated with favorable prognosis. In this review, we present data from an array of studies that demonstrate significantly higher mortality in Black compared to White women with HR+/HER2-breast cancer and contrast these data to studies from integrated healthcare systems that failed to find survival differences. Then, we describe factors, both biological and non-biological, that may contribute to disparate survival in Black women. MDPI 2023-02-07 /pmc/articles/PMC9956998/ /pubmed/36833598 http://dx.doi.org/10.3390/ijerph20042903 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lovejoy, Leann A.
Shriver, Craig D.
Haricharan, Svasti
Ellsworth, Rachel E.
Survival Disparities in US Black Compared to White Women with Hormone Receptor Positive-HER2 Negative Breast Cancer
title Survival Disparities in US Black Compared to White Women with Hormone Receptor Positive-HER2 Negative Breast Cancer
title_full Survival Disparities in US Black Compared to White Women with Hormone Receptor Positive-HER2 Negative Breast Cancer
title_fullStr Survival Disparities in US Black Compared to White Women with Hormone Receptor Positive-HER2 Negative Breast Cancer
title_full_unstemmed Survival Disparities in US Black Compared to White Women with Hormone Receptor Positive-HER2 Negative Breast Cancer
title_short Survival Disparities in US Black Compared to White Women with Hormone Receptor Positive-HER2 Negative Breast Cancer
title_sort survival disparities in us black compared to white women with hormone receptor positive-her2 negative breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9956998/
https://www.ncbi.nlm.nih.gov/pubmed/36833598
http://dx.doi.org/10.3390/ijerph20042903
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