Loss of calpain3b in Zebrafish, a Model of Limb-Girdle Muscular Dystrophy, Increases Susceptibility to Muscle Defects Due to Elevated Muscle Activity

Limb-Girdle Muscular Dystrophy Type R1 (LGMDR1; formerly LGMD2A), characterized by progressive hip and shoulder muscle weakness, is caused by mutations in CAPN3. In zebrafish, capn3b mediates Def-dependent degradation of p53 in the liver and intestines. We show that capn3b is expressed in the muscle...

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Detalles Bibliográficos
Autores principales: Prykhozhij, Sergey V., Caceres, Lucia, Ban, Kevin, Cordeiro-Santanach, Anna, Nagaraju, Kanneboyina, Hoffman, Eric P., Berman, Jason N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9957097/
https://www.ncbi.nlm.nih.gov/pubmed/36833417
http://dx.doi.org/10.3390/genes14020492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9957097/
https://www.ncbi.nlm.nih.gov/pubmed/36833417
http://dx.doi.org/10.3390/genes14020492

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