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Application of Polymer Hydrogels in the Prevention of Postoperative Adhesion: A Review

Postoperative adhesion is a common post-surgery complication formed between the surface of the body cavity, ranging from a layer of connective tissue to a fibrous bridge containing blood vessels and nerve tissue. Despite achieving a lot of progress, the mechanisms of adhesion formation still need to...

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Detalles Bibliográficos
Autores principales: Cai, Jie, Guo, Jiaming, Wang, Shige
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9957106/
https://www.ncbi.nlm.nih.gov/pubmed/36826268
http://dx.doi.org/10.3390/gels9020098
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author Cai, Jie
Guo, Jiaming
Wang, Shige
author_facet Cai, Jie
Guo, Jiaming
Wang, Shige
author_sort Cai, Jie
collection PubMed
description Postoperative adhesion is a common post-surgery complication formed between the surface of the body cavity, ranging from a layer of connective tissue to a fibrous bridge containing blood vessels and nerve tissue. Despite achieving a lot of progress, the mechanisms of adhesion formation still need to be further studied. In addition, few current treatments are consistently effective in the prevention of postoperative adhesion. Hydrogel is a kind of water-expanding crosslinked hydrophilic polymer network generated by a simple reaction of one or more monomers. Due to the porous structure, hydrogels can load different drugs and control the drug release kinetics. Evidence from existing studies has confirmed the feasibility and superiority of using hydrogels to counter postoperative adhesions, primarily due to their outstanding antifouling ability. In this review, the current research status of hydrogels as anti-adhesion barriers is summarized, the character of hydrogels in the prevention of postoperative adhesion is briefly introduced, and future research directions are discussed.
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spelling pubmed-99571062023-02-25 Application of Polymer Hydrogels in the Prevention of Postoperative Adhesion: A Review Cai, Jie Guo, Jiaming Wang, Shige Gels Review Postoperative adhesion is a common post-surgery complication formed between the surface of the body cavity, ranging from a layer of connective tissue to a fibrous bridge containing blood vessels and nerve tissue. Despite achieving a lot of progress, the mechanisms of adhesion formation still need to be further studied. In addition, few current treatments are consistently effective in the prevention of postoperative adhesion. Hydrogel is a kind of water-expanding crosslinked hydrophilic polymer network generated by a simple reaction of one or more monomers. Due to the porous structure, hydrogels can load different drugs and control the drug release kinetics. Evidence from existing studies has confirmed the feasibility and superiority of using hydrogels to counter postoperative adhesions, primarily due to their outstanding antifouling ability. In this review, the current research status of hydrogels as anti-adhesion barriers is summarized, the character of hydrogels in the prevention of postoperative adhesion is briefly introduced, and future research directions are discussed. MDPI 2023-01-23 /pmc/articles/PMC9957106/ /pubmed/36826268 http://dx.doi.org/10.3390/gels9020098 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cai, Jie
Guo, Jiaming
Wang, Shige
Application of Polymer Hydrogels in the Prevention of Postoperative Adhesion: A Review
title Application of Polymer Hydrogels in the Prevention of Postoperative Adhesion: A Review
title_full Application of Polymer Hydrogels in the Prevention of Postoperative Adhesion: A Review
title_fullStr Application of Polymer Hydrogels in the Prevention of Postoperative Adhesion: A Review
title_full_unstemmed Application of Polymer Hydrogels in the Prevention of Postoperative Adhesion: A Review
title_short Application of Polymer Hydrogels in the Prevention of Postoperative Adhesion: A Review
title_sort application of polymer hydrogels in the prevention of postoperative adhesion: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9957106/
https://www.ncbi.nlm.nih.gov/pubmed/36826268
http://dx.doi.org/10.3390/gels9020098
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