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Altered Nucleotide Insertion Mechanisms of Disease-Associated TERT Variants

Telomere biology disorders (TBDs) are a spectrum of diseases that arise from mutations in genes responsible for maintaining telomere integrity. Human telomerase reverse transcriptase (hTERT) adds nucleotides to chromosome ends and is frequently mutated in individuals with TBDs. Previous studies have...

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Detalles Bibliográficos
Autores principales:	Welfer, Griffin A., Borin, Veniamin A., Cortez, Luis M., Opresko, Patricia L., Agarwal, Pratul K., Freudenthal, Bret D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9957172/ https://www.ncbi.nlm.nih.gov/pubmed/36833208 http://dx.doi.org/10.3390/genes14020281

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