Increased On-Target Rate and Risk of Concatemerization after CRISPR-Enhanced Targeting in ES Cells

The French mouse clinic (Institut Clinique de la Souris; ICS) has produced more than 2000 targeting vectors for ‘à la carte’ mutagenesis in C57BL/6N mice. Although most of the vectors were used successfully for homologous recombination in murine embryonic stem cells (ESCs), a few have failed to targ...

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Detalles Bibliográficos
Autores principales: Erbs, Valérie, Lorentz, Romain, Eisenman, Benjamin, Schaeffer, Laurence, Luppi, Laurence, Lindner, Loic, Hérault, Yann, Pavlovic, Guillaume, Wattenhofer-Donzé, Marie, Birling, Marie-Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9957269/
https://www.ncbi.nlm.nih.gov/pubmed/36833328
http://dx.doi.org/10.3390/genes14020401

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9957269/
https://www.ncbi.nlm.nih.gov/pubmed/36833328
http://dx.doi.org/10.3390/genes14020401

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