Patched Homolog 1 (PTCH1) Mutation in a CIC-Rearranged Sarcoma: Lack of Response to the Smoothened (SMO) Vismodegib

Next-generation sequencing (NGS) to identify potential targets is becoming a common approach to refractory tumors. We describe a patient with a CIC-DUX4 sarcoma that harbored a patched homolog 1 (PTCH1) mutation, a mutation not previously reported in so-called Ewing family tumors. PTCH1 is part of t...

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Detalles Bibliográficos
Autores principales: Wu, David J, Murugan, Paari, Skubitz, Keith M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9957587/
https://www.ncbi.nlm.nih.gov/pubmed/36843760
http://dx.doi.org/10.7759/cureus.34281

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9957587/
https://www.ncbi.nlm.nih.gov/pubmed/36843760
http://dx.doi.org/10.7759/cureus.34281

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