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GPR65 as a potential immune checkpoint regulates the immune microenvironment according to pan-cancer analysis

It has been reported that inhibition of GPR65 may be effective for the treatment of certain cancers. Nevertheless, the role of GPR65 in various cancers remains unknown. We conducted an exhaustive pan-cancer analysis of GPR65 using multiple databases, including TCGA, GTEx, BioGPS, HPA, cBioPortal, an...

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Autores principales: Wang, Liangliang, Sun, Lele, Sun, Hao, Xing, Yunhong, Zhou, Shidong, An, Guoshuai, Li, Jian, Ren, Kang, Sun, Junhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9957717/
https://www.ncbi.nlm.nih.gov/pubmed/36852075
http://dx.doi.org/10.1016/j.heliyon.2023.e13617
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author Wang, Liangliang
Sun, Lele
Sun, Hao
Xing, Yunhong
Zhou, Shidong
An, Guoshuai
Li, Jian
Ren, Kang
Sun, Junhong
author_facet Wang, Liangliang
Sun, Lele
Sun, Hao
Xing, Yunhong
Zhou, Shidong
An, Guoshuai
Li, Jian
Ren, Kang
Sun, Junhong
author_sort Wang, Liangliang
collection PubMed
description It has been reported that inhibition of GPR65 may be effective for the treatment of certain cancers. Nevertheless, the role of GPR65 in various cancers remains unknown. We conducted an exhaustive pan-cancer analysis of GPR65 using multiple databases, including TCGA, GTEx, BioGPS, HPA, cBioPortal, and GeneCards. GPR65 was found to be differentially expressed in various cancers and linked to tumor mutational burden (TMB), microsatellite instability (MSI), and Ploidy, playing a key function in the tumor microenvironment (TME). It is closely linked to the development of Th17 cells as well as Th1 and Th2 cells in certain cancers. Our findings indicate that the expression of GPR65 is highly linked with clinical prognosis, mutations, and immune cell infiltration. It was revealed as an indicator of patient prognosis as well as a possible immunomodulatory role. As a possible new immunological checkpoint, GPR65 could be a target for tumor immunotherapy.
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spelling pubmed-99577172023-02-26 GPR65 as a potential immune checkpoint regulates the immune microenvironment according to pan-cancer analysis Wang, Liangliang Sun, Lele Sun, Hao Xing, Yunhong Zhou, Shidong An, Guoshuai Li, Jian Ren, Kang Sun, Junhong Heliyon Research Article It has been reported that inhibition of GPR65 may be effective for the treatment of certain cancers. Nevertheless, the role of GPR65 in various cancers remains unknown. We conducted an exhaustive pan-cancer analysis of GPR65 using multiple databases, including TCGA, GTEx, BioGPS, HPA, cBioPortal, and GeneCards. GPR65 was found to be differentially expressed in various cancers and linked to tumor mutational burden (TMB), microsatellite instability (MSI), and Ploidy, playing a key function in the tumor microenvironment (TME). It is closely linked to the development of Th17 cells as well as Th1 and Th2 cells in certain cancers. Our findings indicate that the expression of GPR65 is highly linked with clinical prognosis, mutations, and immune cell infiltration. It was revealed as an indicator of patient prognosis as well as a possible immunomodulatory role. As a possible new immunological checkpoint, GPR65 could be a target for tumor immunotherapy. Elsevier 2023-02-10 /pmc/articles/PMC9957717/ /pubmed/36852075 http://dx.doi.org/10.1016/j.heliyon.2023.e13617 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Wang, Liangliang
Sun, Lele
Sun, Hao
Xing, Yunhong
Zhou, Shidong
An, Guoshuai
Li, Jian
Ren, Kang
Sun, Junhong
GPR65 as a potential immune checkpoint regulates the immune microenvironment according to pan-cancer analysis
title GPR65 as a potential immune checkpoint regulates the immune microenvironment according to pan-cancer analysis
title_full GPR65 as a potential immune checkpoint regulates the immune microenvironment according to pan-cancer analysis
title_fullStr GPR65 as a potential immune checkpoint regulates the immune microenvironment according to pan-cancer analysis
title_full_unstemmed GPR65 as a potential immune checkpoint regulates the immune microenvironment according to pan-cancer analysis
title_short GPR65 as a potential immune checkpoint regulates the immune microenvironment according to pan-cancer analysis
title_sort gpr65 as a potential immune checkpoint regulates the immune microenvironment according to pan-cancer analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9957717/
https://www.ncbi.nlm.nih.gov/pubmed/36852075
http://dx.doi.org/10.1016/j.heliyon.2023.e13617
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