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DNAsmart: Multiple attribute ranking tool for DNA data storage systems

In an ever-growing need for data storage capacity, the Deoxyribonucleic Acid (DNA) molecule gains traction as a new storage medium with a larger capacity, higher density, and a longer lifespan over conventional storage media. To effectively use DNA for data storage, it is important to understand the...

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Autores principales: Ezekannagha, Chisom, Welzel, Marius, Heider, Dominik, Hattab, Georges
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9957737/
https://www.ncbi.nlm.nih.gov/pubmed/36851917
http://dx.doi.org/10.1016/j.csbj.2023.02.016
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author Ezekannagha, Chisom
Welzel, Marius
Heider, Dominik
Hattab, Georges
author_facet Ezekannagha, Chisom
Welzel, Marius
Heider, Dominik
Hattab, Georges
author_sort Ezekannagha, Chisom
collection PubMed
description In an ever-growing need for data storage capacity, the Deoxyribonucleic Acid (DNA) molecule gains traction as a new storage medium with a larger capacity, higher density, and a longer lifespan over conventional storage media. To effectively use DNA for data storage, it is important to understand the different methods of encoding information in DNA and compare their effectiveness. This requires evaluating which decoded DNA sequences carry the most encoded information based on various attributes. However, navigating the field of coding theory requires years of experience and domain expertise. For instance, domain experts rely on various mathematical functions and attributes to score and evaluate their encodings. To enable such analytical tasks, we provide an interactive and visual analytical framework for multi-attribute ranking in DNA storage systems. Our framework follows a three-step view with user-settable parameters. It enables users to find the optimal en-/de-coding approaches by setting different weights and combining multiple attributes. We assess the validity of our work through a task-specific user study on domain experts by relying on three tasks. Results indicate that all participants completed their tasks successfully under two minutes, then rated the framework for design choices, perceived usefulness, and intuitiveness. In addition, two real-world use cases are shared and analyzed as direct applications of the proposed tool. DNAsmart enables the ranking of decoded sequences based on multiple attributes. In sum, this work unveils the evaluation of en-/de-coding approaches accessible and tractable through visualization and interactivity to solve comparison and ranking tasks.
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spelling pubmed-99577372023-02-26 DNAsmart: Multiple attribute ranking tool for DNA data storage systems Ezekannagha, Chisom Welzel, Marius Heider, Dominik Hattab, Georges Comput Struct Biotechnol J Software/Web Server Article In an ever-growing need for data storage capacity, the Deoxyribonucleic Acid (DNA) molecule gains traction as a new storage medium with a larger capacity, higher density, and a longer lifespan over conventional storage media. To effectively use DNA for data storage, it is important to understand the different methods of encoding information in DNA and compare their effectiveness. This requires evaluating which decoded DNA sequences carry the most encoded information based on various attributes. However, navigating the field of coding theory requires years of experience and domain expertise. For instance, domain experts rely on various mathematical functions and attributes to score and evaluate their encodings. To enable such analytical tasks, we provide an interactive and visual analytical framework for multi-attribute ranking in DNA storage systems. Our framework follows a three-step view with user-settable parameters. It enables users to find the optimal en-/de-coding approaches by setting different weights and combining multiple attributes. We assess the validity of our work through a task-specific user study on domain experts by relying on three tasks. Results indicate that all participants completed their tasks successfully under two minutes, then rated the framework for design choices, perceived usefulness, and intuitiveness. In addition, two real-world use cases are shared and analyzed as direct applications of the proposed tool. DNAsmart enables the ranking of decoded sequences based on multiple attributes. In sum, this work unveils the evaluation of en-/de-coding approaches accessible and tractable through visualization and interactivity to solve comparison and ranking tasks. Research Network of Computational and Structural Biotechnology 2023-02-10 /pmc/articles/PMC9957737/ /pubmed/36851917 http://dx.doi.org/10.1016/j.csbj.2023.02.016 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Software/Web Server Article
Ezekannagha, Chisom
Welzel, Marius
Heider, Dominik
Hattab, Georges
DNAsmart: Multiple attribute ranking tool for DNA data storage systems
title DNAsmart: Multiple attribute ranking tool for DNA data storage systems
title_full DNAsmart: Multiple attribute ranking tool for DNA data storage systems
title_fullStr DNAsmart: Multiple attribute ranking tool for DNA data storage systems
title_full_unstemmed DNAsmart: Multiple attribute ranking tool for DNA data storage systems
title_short DNAsmart: Multiple attribute ranking tool for DNA data storage systems
title_sort dnasmart: multiple attribute ranking tool for dna data storage systems
topic Software/Web Server Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9957737/
https://www.ncbi.nlm.nih.gov/pubmed/36851917
http://dx.doi.org/10.1016/j.csbj.2023.02.016
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