Hepatocyte Smoothened Activity Controls Susceptibility to Insulin Resistance and Nonalcoholic Fatty Liver Disease

BACKGROUND & AIMS: Nonalcoholic steatohepatitis (NASH), a leading cause of cirrhosis, strongly associates with the metabolic syndrome, an insulin-resistant proinflammatory state that disrupts energy balance and promotes progressive liver degeneration. We aimed to define the role of Smoothened (S...

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Detalles Bibliográficos
Autores principales: Chen, Tianyi, Dalton, George, Oh, Seh-Hoon, Maeso-Diaz, Raquel, Du, Kuo, Meyers, Rachel A., Guy, Cynthia, Abdelmalek, Manal F., Henao, Ricardo, Guarnieri, Paolo, Pullen, Steven S., Gregory, Simon, Locker, Joseph, Brown, J. Mark, Diehl, Anna Mae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9957752/
https://www.ncbi.nlm.nih.gov/pubmed/36535507
http://dx.doi.org/10.1016/j.jcmgh.2022.12.008

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