The mTORC1–G9a–H3K9me2 axis negatively regulates autophagy in fatty acid–induced hepatocellular lipotoxicity

Defective autophagy and lipotoxicity are the hallmarks of nonalcoholic fatty liver disease. However, the precise molecular mechanism for the defective autophagy in lipotoxic conditions is not fully known. In the current study, we elucidated that activation of the mammalian target of rapamycin comple...

Descripción completa

Detalles Bibliográficos
Autores principales: Mushtaq, Arjamand, Ashraf, Nissar Ul, Altaf, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9957777/
https://www.ncbi.nlm.nih.gov/pubmed/36690274
http://dx.doi.org/10.1016/j.jbc.2023.102937

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9957777/
https://www.ncbi.nlm.nih.gov/pubmed/36690274
http://dx.doi.org/10.1016/j.jbc.2023.102937

Ejemplares similares