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Impact of age on unicompartmental knee arthroplasty outcomes: a systematic review and meta-analysis

PURPOSE: Unicompartmental knee arthroplasty (UKA) is an effective treatment for late knee osteoarthritis (OA). Young age (< 60 years) has been associated with worse outcomes. The goal of this systematic review and meta-analysis is to study the effect of age on UKA outcomes. METHODS: The primary o...

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Autores principales: Salman, Loay A., Abudalou, Abedallah, Khatkar, Harman, Ahmed, Ghalib, Dakin, Stephanie G., Kendrick, Benjamin, Murray, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9957860/
https://www.ncbi.nlm.nih.gov/pubmed/36063186
http://dx.doi.org/10.1007/s00167-022-07132-x
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author Salman, Loay A.
Abudalou, Abedallah
Khatkar, Harman
Ahmed, Ghalib
Dakin, Stephanie G.
Kendrick, Benjamin
Murray, David W.
author_facet Salman, Loay A.
Abudalou, Abedallah
Khatkar, Harman
Ahmed, Ghalib
Dakin, Stephanie G.
Kendrick, Benjamin
Murray, David W.
author_sort Salman, Loay A.
collection PubMed
description PURPOSE: Unicompartmental knee arthroplasty (UKA) is an effective treatment for late knee osteoarthritis (OA). Young age (< 60 years) has been associated with worse outcomes. The goal of this systematic review and meta-analysis is to study the effect of age on UKA outcomes. METHODS: The primary objective was to compare the UKA revision rate in young patients with that of old patients, using the age thresholds of 60 and 55 years. Secondary objectives were patient-reported outcome measures (PROMs) and implant design. Five databases were searched in December 2021 for original comparative studies with a minimum of 1-year follow-up. No restrictions were placed on the type of UKA prosthesis. RESULTS: A total of 11 observational studies with 6130 knees were included. A mean MINORS score of 19 was assigned to the review. The mean age of patients was 64 years, with average follow-up of 7.5 ± 2.98 years. There was no significant difference in revision rate, incident or PROMs between young and old patients in the analysis for each age threshold. Further sub-analysis adjusting for implant type in mobile- and fixed-bearing prostheses also showed similar results between those above and under 60 and 55 years. CONCLUSION: Young age was not associated with a higher revision rate or lower functional scores. Thus, this review provides evidence that age alone is not a contraindication to UKA, but the surgical choice must be based on several elements, and this finding should be applied in context, given the binary division and heterogeneity of patients. LEVEL OF EVIDENCE: III.
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spelling pubmed-99578602023-02-26 Impact of age on unicompartmental knee arthroplasty outcomes: a systematic review and meta-analysis Salman, Loay A. Abudalou, Abedallah Khatkar, Harman Ahmed, Ghalib Dakin, Stephanie G. Kendrick, Benjamin Murray, David W. Knee Surg Sports Traumatol Arthrosc Knee PURPOSE: Unicompartmental knee arthroplasty (UKA) is an effective treatment for late knee osteoarthritis (OA). Young age (< 60 years) has been associated with worse outcomes. The goal of this systematic review and meta-analysis is to study the effect of age on UKA outcomes. METHODS: The primary objective was to compare the UKA revision rate in young patients with that of old patients, using the age thresholds of 60 and 55 years. Secondary objectives were patient-reported outcome measures (PROMs) and implant design. Five databases were searched in December 2021 for original comparative studies with a minimum of 1-year follow-up. No restrictions were placed on the type of UKA prosthesis. RESULTS: A total of 11 observational studies with 6130 knees were included. A mean MINORS score of 19 was assigned to the review. The mean age of patients was 64 years, with average follow-up of 7.5 ± 2.98 years. There was no significant difference in revision rate, incident or PROMs between young and old patients in the analysis for each age threshold. Further sub-analysis adjusting for implant type in mobile- and fixed-bearing prostheses also showed similar results between those above and under 60 and 55 years. CONCLUSION: Young age was not associated with a higher revision rate or lower functional scores. Thus, this review provides evidence that age alone is not a contraindication to UKA, but the surgical choice must be based on several elements, and this finding should be applied in context, given the binary division and heterogeneity of patients. LEVEL OF EVIDENCE: III. Springer Berlin Heidelberg 2022-09-05 2023 /pmc/articles/PMC9957860/ /pubmed/36063186 http://dx.doi.org/10.1007/s00167-022-07132-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Knee
Salman, Loay A.
Abudalou, Abedallah
Khatkar, Harman
Ahmed, Ghalib
Dakin, Stephanie G.
Kendrick, Benjamin
Murray, David W.
Impact of age on unicompartmental knee arthroplasty outcomes: a systematic review and meta-analysis
title Impact of age on unicompartmental knee arthroplasty outcomes: a systematic review and meta-analysis
title_full Impact of age on unicompartmental knee arthroplasty outcomes: a systematic review and meta-analysis
title_fullStr Impact of age on unicompartmental knee arthroplasty outcomes: a systematic review and meta-analysis
title_full_unstemmed Impact of age on unicompartmental knee arthroplasty outcomes: a systematic review and meta-analysis
title_short Impact of age on unicompartmental knee arthroplasty outcomes: a systematic review and meta-analysis
title_sort impact of age on unicompartmental knee arthroplasty outcomes: a systematic review and meta-analysis
topic Knee
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9957860/
https://www.ncbi.nlm.nih.gov/pubmed/36063186
http://dx.doi.org/10.1007/s00167-022-07132-x
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