Gasdermin-D activation promotes NLRP3 activation and host resistance to Leishmania infection

Intracellular parasites from the Leishmania genus cause Leishmaniasis, a disease affecting millions of people worldwide. NLRP3 inflammasome is key for disease outcome, but the molecular mechanisms upstream of the inflammasome activation are still unclear. Here, we demonstrate that despite the absenc...

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Detalles Bibliográficos
Autores principales: de Sá, Keyla S. G., Amaral, Luana A., Rodrigues, Tamara S., Ishimoto, Adriene Y., de Andrade, Warrison A. C., de Almeida, Leticia, Freitas-Castro, Felipe, Batah, Sabrina S., Oliveira, Sergio C., Pastorello, Mônica T., Fabro, Alexandre T., Zamboni, Dario S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958042/
https://www.ncbi.nlm.nih.gov/pubmed/36828815
http://dx.doi.org/10.1038/s41467-023-36626-6

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