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A campaign of mass drug administration with artemisinin-piperaquine to antimalaria in Trobriand Islands
We conducted a study on the Trobriand Islands of Papua New Guinea (PNG) in 2018 to verify the safety and efficacy of the artemisinin-piperaquine (AP) mass drug administration (MDA) campaign in regions with moderate to high mixed malaria transmission. Based on the natural topography of the Trobriand...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958052/ https://www.ncbi.nlm.nih.gov/pubmed/36852307 http://dx.doi.org/10.1016/j.pmedr.2023.102154 |
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author | Li, Guoming Zheng, Shaoqin Zhang, Zhenyan Hu, Yanshan Lin, Nansong Julie, Nadia Shu, Lei Sun, Liwei Zhang, Hongying Yuan, Yueming Liang, Yuan Yu, Zhengjie Xie, Wei Mwaisiga, Ridley Morewaya, Jacob Xu, Qin Song, Jianping Deng, Changsheng |
author_facet | Li, Guoming Zheng, Shaoqin Zhang, Zhenyan Hu, Yanshan Lin, Nansong Julie, Nadia Shu, Lei Sun, Liwei Zhang, Hongying Yuan, Yueming Liang, Yuan Yu, Zhengjie Xie, Wei Mwaisiga, Ridley Morewaya, Jacob Xu, Qin Song, Jianping Deng, Changsheng |
author_sort | Li, Guoming |
collection | PubMed |
description | We conducted a study on the Trobriand Islands of Papua New Guinea (PNG) in 2018 to verify the safety and efficacy of the artemisinin-piperaquine (AP) mass drug administration (MDA) campaign in regions with moderate to high mixed malaria transmission. Based on the natural topography of the Trobriand Islands, 44,855 residents from 92 villages on the islands were enrolled and divided into the main and outer islands. Three rounds of MDA were conducted using grid-based management. The primary endpoint was the coverage rate. Adverse reactions, parasitemia, and malaria morbidity were the secondary endpoints. There were 36,716 people living in 75 villages on the main island, and the MDA coverage rate was 92.58–95.68%. Furthermore, 8,139 people living in 17 villages on the outer islands had a coverage rate of 94.93–96.11%. The adverse reactions were mild in both groups, and parasitemia decreased by 87.2% after one year of surveillance. The average annual malaria morbidity has decreased by 89.3% after the program for four years. High compliance and mild adverse reactions indicated that the MDA campaign with AP was safe. The short-term effect is relatively ideal, but the evidence for long-term effect evaluation is insufficient. |
format | Online Article Text |
id | pubmed-9958052 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
record_format | MEDLINE/PubMed |
spelling | pubmed-99580522023-02-26 A campaign of mass drug administration with artemisinin-piperaquine to antimalaria in Trobriand Islands Li, Guoming Zheng, Shaoqin Zhang, Zhenyan Hu, Yanshan Lin, Nansong Julie, Nadia Shu, Lei Sun, Liwei Zhang, Hongying Yuan, Yueming Liang, Yuan Yu, Zhengjie Xie, Wei Mwaisiga, Ridley Morewaya, Jacob Xu, Qin Song, Jianping Deng, Changsheng Prev Med Rep Regular Article We conducted a study on the Trobriand Islands of Papua New Guinea (PNG) in 2018 to verify the safety and efficacy of the artemisinin-piperaquine (AP) mass drug administration (MDA) campaign in regions with moderate to high mixed malaria transmission. Based on the natural topography of the Trobriand Islands, 44,855 residents from 92 villages on the islands were enrolled and divided into the main and outer islands. Three rounds of MDA were conducted using grid-based management. The primary endpoint was the coverage rate. Adverse reactions, parasitemia, and malaria morbidity were the secondary endpoints. There were 36,716 people living in 75 villages on the main island, and the MDA coverage rate was 92.58–95.68%. Furthermore, 8,139 people living in 17 villages on the outer islands had a coverage rate of 94.93–96.11%. The adverse reactions were mild in both groups, and parasitemia decreased by 87.2% after one year of surveillance. The average annual malaria morbidity has decreased by 89.3% after the program for four years. High compliance and mild adverse reactions indicated that the MDA campaign with AP was safe. The short-term effect is relatively ideal, but the evidence for long-term effect evaluation is insufficient. 2023-02-16 /pmc/articles/PMC9958052/ /pubmed/36852307 http://dx.doi.org/10.1016/j.pmedr.2023.102154 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Regular Article Li, Guoming Zheng, Shaoqin Zhang, Zhenyan Hu, Yanshan Lin, Nansong Julie, Nadia Shu, Lei Sun, Liwei Zhang, Hongying Yuan, Yueming Liang, Yuan Yu, Zhengjie Xie, Wei Mwaisiga, Ridley Morewaya, Jacob Xu, Qin Song, Jianping Deng, Changsheng A campaign of mass drug administration with artemisinin-piperaquine to antimalaria in Trobriand Islands |
title | A campaign of mass drug administration with artemisinin-piperaquine to antimalaria in Trobriand Islands |
title_full | A campaign of mass drug administration with artemisinin-piperaquine to antimalaria in Trobriand Islands |
title_fullStr | A campaign of mass drug administration with artemisinin-piperaquine to antimalaria in Trobriand Islands |
title_full_unstemmed | A campaign of mass drug administration with artemisinin-piperaquine to antimalaria in Trobriand Islands |
title_short | A campaign of mass drug administration with artemisinin-piperaquine to antimalaria in Trobriand Islands |
title_sort | campaign of mass drug administration with artemisinin-piperaquine to antimalaria in trobriand islands |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958052/ https://www.ncbi.nlm.nih.gov/pubmed/36852307 http://dx.doi.org/10.1016/j.pmedr.2023.102154 |
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