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A campaign of mass drug administration with artemisinin-piperaquine to antimalaria in Trobriand Islands

We conducted a study on the Trobriand Islands of Papua New Guinea (PNG) in 2018 to verify the safety and efficacy of the artemisinin-piperaquine (AP) mass drug administration (MDA) campaign in regions with moderate to high mixed malaria transmission. Based on the natural topography of the Trobriand...

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Autores principales: Li, Guoming, Zheng, Shaoqin, Zhang, Zhenyan, Hu, Yanshan, Lin, Nansong, Julie, Nadia, Shu, Lei, Sun, Liwei, Zhang, Hongying, Yuan, Yueming, Liang, Yuan, Yu, Zhengjie, Xie, Wei, Mwaisiga, Ridley, Morewaya, Jacob, Xu, Qin, Song, Jianping, Deng, Changsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958052/
https://www.ncbi.nlm.nih.gov/pubmed/36852307
http://dx.doi.org/10.1016/j.pmedr.2023.102154
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author Li, Guoming
Zheng, Shaoqin
Zhang, Zhenyan
Hu, Yanshan
Lin, Nansong
Julie, Nadia
Shu, Lei
Sun, Liwei
Zhang, Hongying
Yuan, Yueming
Liang, Yuan
Yu, Zhengjie
Xie, Wei
Mwaisiga, Ridley
Morewaya, Jacob
Xu, Qin
Song, Jianping
Deng, Changsheng
author_facet Li, Guoming
Zheng, Shaoqin
Zhang, Zhenyan
Hu, Yanshan
Lin, Nansong
Julie, Nadia
Shu, Lei
Sun, Liwei
Zhang, Hongying
Yuan, Yueming
Liang, Yuan
Yu, Zhengjie
Xie, Wei
Mwaisiga, Ridley
Morewaya, Jacob
Xu, Qin
Song, Jianping
Deng, Changsheng
author_sort Li, Guoming
collection PubMed
description We conducted a study on the Trobriand Islands of Papua New Guinea (PNG) in 2018 to verify the safety and efficacy of the artemisinin-piperaquine (AP) mass drug administration (MDA) campaign in regions with moderate to high mixed malaria transmission. Based on the natural topography of the Trobriand Islands, 44,855 residents from 92 villages on the islands were enrolled and divided into the main and outer islands. Three rounds of MDA were conducted using grid-based management. The primary endpoint was the coverage rate. Adverse reactions, parasitemia, and malaria morbidity were the secondary endpoints. There were 36,716 people living in 75 villages on the main island, and the MDA coverage rate was 92.58–95.68%. Furthermore, 8,139 people living in 17 villages on the outer islands had a coverage rate of 94.93–96.11%. The adverse reactions were mild in both groups, and parasitemia decreased by 87.2% after one year of surveillance. The average annual malaria morbidity has decreased by 89.3% after the program for four years. High compliance and mild adverse reactions indicated that the MDA campaign with AP was safe. The short-term effect is relatively ideal, but the evidence for long-term effect evaluation is insufficient.
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spelling pubmed-99580522023-02-26 A campaign of mass drug administration with artemisinin-piperaquine to antimalaria in Trobriand Islands Li, Guoming Zheng, Shaoqin Zhang, Zhenyan Hu, Yanshan Lin, Nansong Julie, Nadia Shu, Lei Sun, Liwei Zhang, Hongying Yuan, Yueming Liang, Yuan Yu, Zhengjie Xie, Wei Mwaisiga, Ridley Morewaya, Jacob Xu, Qin Song, Jianping Deng, Changsheng Prev Med Rep Regular Article We conducted a study on the Trobriand Islands of Papua New Guinea (PNG) in 2018 to verify the safety and efficacy of the artemisinin-piperaquine (AP) mass drug administration (MDA) campaign in regions with moderate to high mixed malaria transmission. Based on the natural topography of the Trobriand Islands, 44,855 residents from 92 villages on the islands were enrolled and divided into the main and outer islands. Three rounds of MDA were conducted using grid-based management. The primary endpoint was the coverage rate. Adverse reactions, parasitemia, and malaria morbidity were the secondary endpoints. There were 36,716 people living in 75 villages on the main island, and the MDA coverage rate was 92.58–95.68%. Furthermore, 8,139 people living in 17 villages on the outer islands had a coverage rate of 94.93–96.11%. The adverse reactions were mild in both groups, and parasitemia decreased by 87.2% after one year of surveillance. The average annual malaria morbidity has decreased by 89.3% after the program for four years. High compliance and mild adverse reactions indicated that the MDA campaign with AP was safe. The short-term effect is relatively ideal, but the evidence for long-term effect evaluation is insufficient. 2023-02-16 /pmc/articles/PMC9958052/ /pubmed/36852307 http://dx.doi.org/10.1016/j.pmedr.2023.102154 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Regular Article
Li, Guoming
Zheng, Shaoqin
Zhang, Zhenyan
Hu, Yanshan
Lin, Nansong
Julie, Nadia
Shu, Lei
Sun, Liwei
Zhang, Hongying
Yuan, Yueming
Liang, Yuan
Yu, Zhengjie
Xie, Wei
Mwaisiga, Ridley
Morewaya, Jacob
Xu, Qin
Song, Jianping
Deng, Changsheng
A campaign of mass drug administration with artemisinin-piperaquine to antimalaria in Trobriand Islands
title A campaign of mass drug administration with artemisinin-piperaquine to antimalaria in Trobriand Islands
title_full A campaign of mass drug administration with artemisinin-piperaquine to antimalaria in Trobriand Islands
title_fullStr A campaign of mass drug administration with artemisinin-piperaquine to antimalaria in Trobriand Islands
title_full_unstemmed A campaign of mass drug administration with artemisinin-piperaquine to antimalaria in Trobriand Islands
title_short A campaign of mass drug administration with artemisinin-piperaquine to antimalaria in Trobriand Islands
title_sort campaign of mass drug administration with artemisinin-piperaquine to antimalaria in trobriand islands
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958052/
https://www.ncbi.nlm.nih.gov/pubmed/36852307
http://dx.doi.org/10.1016/j.pmedr.2023.102154
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