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Rapid response screening for emerging zoonotic pathogens, barriers and opportunities: A study for enhanced preparedness of the Netherlands

BACKGROUND: Outbreaks of zoonotic emerging infectious diseases (EIDs) require rapid identification of potential reservoir hosts and mapping disease spread in these hosts to inform risk assessment and adequate control measures. Animals are often understudied when a novel EID is detected in humans and...

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Autores principales: Streng, Kiki, de Best, Pauline A., Timen, Aura, Koopmans, Marion P.G., van der Poel, Wim H.M., Sikkema, Reina S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958062/
https://www.ncbi.nlm.nih.gov/pubmed/36852195
http://dx.doi.org/10.1016/j.onehlt.2023.100507
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author Streng, Kiki
de Best, Pauline A.
Timen, Aura
Koopmans, Marion P.G.
van der Poel, Wim H.M.
Sikkema, Reina S.
author_facet Streng, Kiki
de Best, Pauline A.
Timen, Aura
Koopmans, Marion P.G.
van der Poel, Wim H.M.
Sikkema, Reina S.
author_sort Streng, Kiki
collection PubMed
description BACKGROUND: Outbreaks of zoonotic emerging infectious diseases (EIDs) require rapid identification of potential reservoir hosts and mapping disease spread in these hosts to inform risk assessment and adequate control measures. Animals are often understudied when a novel EID is detected in humans and acquisition of animal samples is hampered by practical, ethical, and legal barriers, of which there is currently no clear overview. Therefore, the three aims of this study are (1) to map potentially available collections of animal samples, (2) to assess possibilities and barriers for reuse of these samples and (3) to assess possibilities and barriers for active animal and environmental sampling in the Netherlands. METHODS: A literature search was performed to identify ongoing sampling activities and opportunities for reuse or active sampling. Semi-structured interviews with stakeholder organizations were conducted to gain further insight into the three research questions. RESULTS: Various sample collections of surveillance, diagnostic and research activities exist in the Netherlands. Sample size, coverage, storage methods and type of samples collected differs per animal species which influences reuse suitability. Organizations are more likely to share samples, for reuse in outbreak investigations, when they have a pre-existing relationship with the requesting institute. Identified barriers for sharing were, among others, unfamiliarity with legislation and unsuitable data management systems. Active sampling of animals or the environment is possible through several routes. Related barriers are acquiring approval from animal- or property owners, conflicts with anonymization, and time needed to acquire ethical approval. CONCLUSION: The animal sample collections identified would be very valuable for use in outbreak investigations. Barriers for sharing may be overcome by increasing familiarity with legislation, building (international) sharing networks and agreements before crises occur and developing systems for sample registration and biobanking. Proactive setting up of ethical approvals will allow for rapid animal sample collection to identify EID hosts and potential spillovers.
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spelling pubmed-99580622023-02-26 Rapid response screening for emerging zoonotic pathogens, barriers and opportunities: A study for enhanced preparedness of the Netherlands Streng, Kiki de Best, Pauline A. Timen, Aura Koopmans, Marion P.G. van der Poel, Wim H.M. Sikkema, Reina S. One Health Special section on One Health - approach to arboviruses; Edited by Marion Koopmans, Reina Sikkema, Maarten Schrama, Barry Rockx BACKGROUND: Outbreaks of zoonotic emerging infectious diseases (EIDs) require rapid identification of potential reservoir hosts and mapping disease spread in these hosts to inform risk assessment and adequate control measures. Animals are often understudied when a novel EID is detected in humans and acquisition of animal samples is hampered by practical, ethical, and legal barriers, of which there is currently no clear overview. Therefore, the three aims of this study are (1) to map potentially available collections of animal samples, (2) to assess possibilities and barriers for reuse of these samples and (3) to assess possibilities and barriers for active animal and environmental sampling in the Netherlands. METHODS: A literature search was performed to identify ongoing sampling activities and opportunities for reuse or active sampling. Semi-structured interviews with stakeholder organizations were conducted to gain further insight into the three research questions. RESULTS: Various sample collections of surveillance, diagnostic and research activities exist in the Netherlands. Sample size, coverage, storage methods and type of samples collected differs per animal species which influences reuse suitability. Organizations are more likely to share samples, for reuse in outbreak investigations, when they have a pre-existing relationship with the requesting institute. Identified barriers for sharing were, among others, unfamiliarity with legislation and unsuitable data management systems. Active sampling of animals or the environment is possible through several routes. Related barriers are acquiring approval from animal- or property owners, conflicts with anonymization, and time needed to acquire ethical approval. CONCLUSION: The animal sample collections identified would be very valuable for use in outbreak investigations. Barriers for sharing may be overcome by increasing familiarity with legislation, building (international) sharing networks and agreements before crises occur and developing systems for sample registration and biobanking. Proactive setting up of ethical approvals will allow for rapid animal sample collection to identify EID hosts and potential spillovers. Elsevier 2023-02-14 /pmc/articles/PMC9958062/ /pubmed/36852195 http://dx.doi.org/10.1016/j.onehlt.2023.100507 Text en © 2023 Published by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Special section on One Health - approach to arboviruses; Edited by Marion Koopmans, Reina Sikkema, Maarten Schrama, Barry Rockx
Streng, Kiki
de Best, Pauline A.
Timen, Aura
Koopmans, Marion P.G.
van der Poel, Wim H.M.
Sikkema, Reina S.
Rapid response screening for emerging zoonotic pathogens, barriers and opportunities: A study for enhanced preparedness of the Netherlands
title Rapid response screening for emerging zoonotic pathogens, barriers and opportunities: A study for enhanced preparedness of the Netherlands
title_full Rapid response screening for emerging zoonotic pathogens, barriers and opportunities: A study for enhanced preparedness of the Netherlands
title_fullStr Rapid response screening for emerging zoonotic pathogens, barriers and opportunities: A study for enhanced preparedness of the Netherlands
title_full_unstemmed Rapid response screening for emerging zoonotic pathogens, barriers and opportunities: A study for enhanced preparedness of the Netherlands
title_short Rapid response screening for emerging zoonotic pathogens, barriers and opportunities: A study for enhanced preparedness of the Netherlands
title_sort rapid response screening for emerging zoonotic pathogens, barriers and opportunities: a study for enhanced preparedness of the netherlands
topic Special section on One Health - approach to arboviruses; Edited by Marion Koopmans, Reina Sikkema, Maarten Schrama, Barry Rockx
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958062/
https://www.ncbi.nlm.nih.gov/pubmed/36852195
http://dx.doi.org/10.1016/j.onehlt.2023.100507
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