Adipocyte-specific FXR-deficiency protects adipose tissue from oxidative stress and insulin resistance and improves glucose homeostasis

OBJECTIVE: Obesity is associated with metabolic dysfunction of white adipose tissue (WAT). Activated adipocytes secrete pro-inflammatory cytokines resulting in the recruitment of pro-inflammatory macrophages, which contribute to WAT insulin resistance. The bile acid (BA)-activated nuclear Farnesoid...

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Detalles Bibliográficos
Autores principales: Dehondt, Hélène, Marino, Arianna, Butruille, Laura, Mogilenko, Denis A., Nzoussi Loubota, Arielle C., Chávez-Talavera, Oscar, Dorchies, Emilie, Vallez, Emmanuelle, Haas, Joel, Derudas, Bruno, Bongiovanni, Antonino, Tardivel, Meryem, Kuipers, Folkert, Lefebvre, Philippe, Lestavel, Sophie, Tailleux, Anne, Dombrowicz, David, Caron, Sandrine, Staels, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958065/
https://www.ncbi.nlm.nih.gov/pubmed/36746333
http://dx.doi.org/10.1016/j.molmet.2023.101686

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