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Molecular engineering of a minimal E-cadherin inhibitor protein derived from Clostridium botulinum hemagglutinin

Hemagglutinin (HA), a nontoxic component of the botulinum neurotoxin (BoNT) complex, binds to E-cadherin and inhibits E-cadherin-mediated cell–cell adhesion. HA is a 470 kDa protein complex comprising six HA1, three HA2, and three HA3 subcomponents. Thus, to prepare recombinant full-length HA in vit...

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Detalles Bibliográficos
Autores principales:	Amatsu, Sho, Matsumura, Takuhiro, Zuka, Masahiko, Fujinaga, Yukako
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958082/ https://www.ncbi.nlm.nih.gov/pubmed/36707052 http://dx.doi.org/10.1016/j.jbc.2023.102944

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