The cofactor-dependent folding mechanism of Drosophila cryptochrome revealed by single-molecule pulling experiments

The link between cofactor binding and protein activity is well-established. However, how cofactor interactions modulate folding of large proteins remains unknown. We use optical tweezers, clustering and global fitting to dissect the folding mechanism of Drosophila cryptochrome (dCRY), a 542-residue...

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Detalles Bibliográficos
Autores principales: Foroutannejad, Sahar, Good, Lydia L., Lin, Changfan, Carter, Zachariah I., Tadesse, Mahlet G., Lucius, Aaron L., Crane, Brian R., Maillard, Rodrigo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958137/
https://www.ncbi.nlm.nih.gov/pubmed/36828841
http://dx.doi.org/10.1038/s41467-023-36701-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958137/
https://www.ncbi.nlm.nih.gov/pubmed/36828841
http://dx.doi.org/10.1038/s41467-023-36701-y

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