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The cofactor-dependent folding mechanism of Drosophila cryptochrome revealed by single-molecule pulling experiments
The link between cofactor binding and protein activity is well-established. However, how cofactor interactions modulate folding of large proteins remains unknown. We use optical tweezers, clustering and global fitting to dissect the folding mechanism of Drosophila cryptochrome (dCRY), a 542-residue...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958137/ https://www.ncbi.nlm.nih.gov/pubmed/36828841 http://dx.doi.org/10.1038/s41467-023-36701-y |