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Combined long-term enriched environment and caffeine supplementation improve memory function in C57Bl6 mice

Regular physical activity has been associated with healthy brain aging, reflected by beneficial effects on cognition and learning and memory. Nutritional supplements such as caffeine have been shown to act as cognitive enhancers and may possess neuroprotective properties. Interestingly, caffeine als...

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Autores principales: Stazi, Martina, Zampar, Silvia, Nadolny, Madeleine, Büschgens, Luca, Meyer, Thomas, Wirths, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958139/
https://www.ncbi.nlm.nih.gov/pubmed/35676374
http://dx.doi.org/10.1007/s00406-022-01431-7
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author Stazi, Martina
Zampar, Silvia
Nadolny, Madeleine
Büschgens, Luca
Meyer, Thomas
Wirths, Oliver
author_facet Stazi, Martina
Zampar, Silvia
Nadolny, Madeleine
Büschgens, Luca
Meyer, Thomas
Wirths, Oliver
author_sort Stazi, Martina
collection PubMed
description Regular physical activity has been associated with healthy brain aging, reflected by beneficial effects on cognition and learning and memory. Nutritional supplements such as caffeine have been shown to act as cognitive enhancers and may possess neuroprotective properties. Interestingly, caffeine also improves athletic capabilities and is widely used by athletes because of its performance-enhancing effect, while information on potential additive beneficial effects of physical activity and caffeine on cognitive performance is scarce. In the present study, the effects of caffeine supplementation in combination with prolonged physical and cognitive stimulation in the form of the enriched environment (EE) housing for a duration of 4 months were analyzed. We demonstrate that caffeine supplementation together with prolonged environmental enrichment led to enhanced memory function, resulting in improved recognition and spatial working memory in behavioral paradigms such as the novel object recognition task or the Morris water maze in C57Bl6 wild-type mice. Mice housed under EE conditions showed increased gene expression levels of brain-derived neurotrophic factor (BDNF) in the hippocampus. The present findings underscore the potential impact of continuous physical activity in the prevention of age-related cognitive decline and may offer new options for combinatorial approaches. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00406-022-01431-7.
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spelling pubmed-99581392023-02-26 Combined long-term enriched environment and caffeine supplementation improve memory function in C57Bl6 mice Stazi, Martina Zampar, Silvia Nadolny, Madeleine Büschgens, Luca Meyer, Thomas Wirths, Oliver Eur Arch Psychiatry Clin Neurosci Original Paper Regular physical activity has been associated with healthy brain aging, reflected by beneficial effects on cognition and learning and memory. Nutritional supplements such as caffeine have been shown to act as cognitive enhancers and may possess neuroprotective properties. Interestingly, caffeine also improves athletic capabilities and is widely used by athletes because of its performance-enhancing effect, while information on potential additive beneficial effects of physical activity and caffeine on cognitive performance is scarce. In the present study, the effects of caffeine supplementation in combination with prolonged physical and cognitive stimulation in the form of the enriched environment (EE) housing for a duration of 4 months were analyzed. We demonstrate that caffeine supplementation together with prolonged environmental enrichment led to enhanced memory function, resulting in improved recognition and spatial working memory in behavioral paradigms such as the novel object recognition task or the Morris water maze in C57Bl6 wild-type mice. Mice housed under EE conditions showed increased gene expression levels of brain-derived neurotrophic factor (BDNF) in the hippocampus. The present findings underscore the potential impact of continuous physical activity in the prevention of age-related cognitive decline and may offer new options for combinatorial approaches. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00406-022-01431-7. Springer Berlin Heidelberg 2022-06-09 2023 /pmc/articles/PMC9958139/ /pubmed/35676374 http://dx.doi.org/10.1007/s00406-022-01431-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Paper
Stazi, Martina
Zampar, Silvia
Nadolny, Madeleine
Büschgens, Luca
Meyer, Thomas
Wirths, Oliver
Combined long-term enriched environment and caffeine supplementation improve memory function in C57Bl6 mice
title Combined long-term enriched environment and caffeine supplementation improve memory function in C57Bl6 mice
title_full Combined long-term enriched environment and caffeine supplementation improve memory function in C57Bl6 mice
title_fullStr Combined long-term enriched environment and caffeine supplementation improve memory function in C57Bl6 mice
title_full_unstemmed Combined long-term enriched environment and caffeine supplementation improve memory function in C57Bl6 mice
title_short Combined long-term enriched environment and caffeine supplementation improve memory function in C57Bl6 mice
title_sort combined long-term enriched environment and caffeine supplementation improve memory function in c57bl6 mice
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958139/
https://www.ncbi.nlm.nih.gov/pubmed/35676374
http://dx.doi.org/10.1007/s00406-022-01431-7
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