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Cyclooxygenase-2 activates EGFR–ERK1/2 pathway via PGE2-mediated ADAM-17 signaling in testosterone-induced benign prostatic hyperplasia

OBJECTIVE AND DESIGN: Prostatic inflammation is the driving force in benign prostatic hyperplasia (BPH). This work investigated the potential modulatory effect of COX-2 inhibition on ADAM-17/EGFR/ERK1/2 axis. MATERIALS OR SUBJECTS: Adult male Wistar rats were used. TREATMENT: Celecoxib (10 and 20 mg...

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Detalles Bibliográficos
Autores principales:	Abo-El Fetoh, Mohammed E., Abdel-Fattah, Maha M., Mohamed, Wafaa R., Ramadan, Laila A. A., Afify, Hassan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958186/ https://www.ncbi.nlm.nih.gov/pubmed/36586043 http://dx.doi.org/10.1007/s10787-022-01123-7

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