Real‐world treatment outcomes of sofosbuvir‐based regimens for treatment of chronic hepatitis C with and without human immunodeficiency virus co‐infection

BACKGROUND AND AIM: The efficacy of sofosbuvir (SOF)‐based regimens in the treatment of chronic hepatitis C (HCV) patients with and without human immunodeficiency virus (HIV) co‐infected patients in real‐world setting is limited. METHODS: This was a retrospective cohort study, conducted between 1 January 2017 and 31 December 2021 at Bamrasnaradura Infectious Disease Institute, Thailand. All HCV patients received 12 weeks of SOF‐based regimens and had follow‐up for at least 12 weeks after therapy discontinuation. The primary outcome was sustained virological response (SVR) at 12 weeks after the end of treatment. Treatment outcomes were compared between HCV patients with and without HIV co‐infection. RESULTS: A total of 163 patients were included in the study, 130 (79.8%) were HCV/HIV co‐infected, and 33 (20.2%) were HCV mono‐infected. Of all, 106 (64%) patients received SOF and ledipasvir. Genotype 1 (GT1) was predominant at 66.4%, followed by GT3 at 22.2%, and GT6 at 11.4%. Overall SVR was 96.9%. SVR in HCV mono‐infected was 96.9% and SVR in HIV‐HCV co‐infected patients was 96.9%. The factor associated with SVR was HCV genotype (P = 0.001). Patients with HCV GT6 had lower SVR rates compared with GT1 and GT3 patients (83.3%, 100%, and 97.1% [P = 0.000] respectively). There was no association between SVR and other factors such as gender, age, BMI, underlying cirrhosis, baseline HCV viral load, or prior treatment history (all P > 0.05). All patients completed 12‐week SOF‐based treatment. CONCLUSION: In real‐world setting, HCV treatment with SOF‐based regimens between patients with and without HIV co‐infection showed high rates of SVR. SOF‐based regimens were highly efficacious and tolerated.