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Seven‐day vonoprazan‐based triple therapy as first‐line Helicobacter pylori treatment in comparison with extended sequential therapy
BACKGROUND AND AIM: Vonoprazan as a new acid blocker has more potency and longer lasting acid suppression than proton pump inhibitors. Whether the efficacy of vonoprazan‐based triple therapy is comparable with or even better than that of currently recommended first‐line therapies is still unknown. O...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wiley Publishing Asia Pty Ltd
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958340/ https://www.ncbi.nlm.nih.gov/pubmed/36852150 http://dx.doi.org/10.1002/jgh3.12858 |
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author | Chiu, Yu‐Tse Lee, Fu‐Jen Kuo, Chen‐Ya Lin, Yang‐Chao Liang, Kai‐Shun Tseng, Liang‐Wei Chen, Yu‐Tsung Chang, Chi‐Yang |
author_facet | Chiu, Yu‐Tse Lee, Fu‐Jen Kuo, Chen‐Ya Lin, Yang‐Chao Liang, Kai‐Shun Tseng, Liang‐Wei Chen, Yu‐Tsung Chang, Chi‐Yang |
author_sort | Chiu, Yu‐Tse |
collection | PubMed |
description | BACKGROUND AND AIM: Vonoprazan as a new acid blocker has more potency and longer lasting acid suppression than proton pump inhibitors. Whether the efficacy of vonoprazan‐based triple therapy is comparable with or even better than that of currently recommended first‐line therapies is still unknown. Our study aims to compare the eradication rate and major adverse effects between 7‐day vonoprazan‐based triple therapy with high‐dose amoxicillin and 14‐day extended sequential therapy. METHODS: We performed a retrospective analysis from the database of (13)C‐urea breath test at Fu Jen Catholic University Hospital. All patients with a definite diagnosis of Helicobacter pylori infection by rapid urease test, urea breath test, stool antigen test, or pathology report were recruited. Patients receiving first‐line regimens with vonoprazan‐based triple therapy or extended sequential therapy were included. The respective eradication rate determined by (13)C‐urea breath test and major adverse effects were demonstrated. RESULTS: Totally, 106 patients were recruited in the vonoprazan‐based triple therapy group and 357 in the extended sequential therapy group. There was no significant difference in eradication rate between vonoprazan‐based triple therapy with high‐dose amoxicillin and extended sequential therapy (83.0 vs 88.8%, P = 0.12). Major adverse effects occurred in 13 of the extended sequential therapy group but none in the other group (0% vs 3.6%, P = 0.046). CONCLUSIONS: Seven‐day vonoprazan‐based triple therapy with high‐dose amoxicillin is a potential first‐line anti‐Helicobacter pylori regimen alternative to current standard treatment, with the advantages of simplicity, short treatment duration, low pill burden, and fewer major adverse effects. |
format | Online Article Text |
id | pubmed-9958340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Wiley Publishing Asia Pty Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-99583402023-02-26 Seven‐day vonoprazan‐based triple therapy as first‐line Helicobacter pylori treatment in comparison with extended sequential therapy Chiu, Yu‐Tse Lee, Fu‐Jen Kuo, Chen‐Ya Lin, Yang‐Chao Liang, Kai‐Shun Tseng, Liang‐Wei Chen, Yu‐Tsung Chang, Chi‐Yang JGH Open Original Articles BACKGROUND AND AIM: Vonoprazan as a new acid blocker has more potency and longer lasting acid suppression than proton pump inhibitors. Whether the efficacy of vonoprazan‐based triple therapy is comparable with or even better than that of currently recommended first‐line therapies is still unknown. Our study aims to compare the eradication rate and major adverse effects between 7‐day vonoprazan‐based triple therapy with high‐dose amoxicillin and 14‐day extended sequential therapy. METHODS: We performed a retrospective analysis from the database of (13)C‐urea breath test at Fu Jen Catholic University Hospital. All patients with a definite diagnosis of Helicobacter pylori infection by rapid urease test, urea breath test, stool antigen test, or pathology report were recruited. Patients receiving first‐line regimens with vonoprazan‐based triple therapy or extended sequential therapy were included. The respective eradication rate determined by (13)C‐urea breath test and major adverse effects were demonstrated. RESULTS: Totally, 106 patients were recruited in the vonoprazan‐based triple therapy group and 357 in the extended sequential therapy group. There was no significant difference in eradication rate between vonoprazan‐based triple therapy with high‐dose amoxicillin and extended sequential therapy (83.0 vs 88.8%, P = 0.12). Major adverse effects occurred in 13 of the extended sequential therapy group but none in the other group (0% vs 3.6%, P = 0.046). CONCLUSIONS: Seven‐day vonoprazan‐based triple therapy with high‐dose amoxicillin is a potential first‐line anti‐Helicobacter pylori regimen alternative to current standard treatment, with the advantages of simplicity, short treatment duration, low pill burden, and fewer major adverse effects. Wiley Publishing Asia Pty Ltd 2023-01-11 /pmc/articles/PMC9958340/ /pubmed/36852150 http://dx.doi.org/10.1002/jgh3.12858 Text en © 2023 The Authors. JGH Open published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Chiu, Yu‐Tse Lee, Fu‐Jen Kuo, Chen‐Ya Lin, Yang‐Chao Liang, Kai‐Shun Tseng, Liang‐Wei Chen, Yu‐Tsung Chang, Chi‐Yang Seven‐day vonoprazan‐based triple therapy as first‐line Helicobacter pylori treatment in comparison with extended sequential therapy |
title |
Seven‐day vonoprazan‐based triple therapy as first‐line
Helicobacter pylori treatment in comparison with extended sequential therapy |
title_full |
Seven‐day vonoprazan‐based triple therapy as first‐line
Helicobacter pylori treatment in comparison with extended sequential therapy |
title_fullStr |
Seven‐day vonoprazan‐based triple therapy as first‐line
Helicobacter pylori treatment in comparison with extended sequential therapy |
title_full_unstemmed |
Seven‐day vonoprazan‐based triple therapy as first‐line
Helicobacter pylori treatment in comparison with extended sequential therapy |
title_short |
Seven‐day vonoprazan‐based triple therapy as first‐line
Helicobacter pylori treatment in comparison with extended sequential therapy |
title_sort | seven‐day vonoprazan‐based triple therapy as first‐line
helicobacter pylori treatment in comparison with extended sequential therapy |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958340/ https://www.ncbi.nlm.nih.gov/pubmed/36852150 http://dx.doi.org/10.1002/jgh3.12858 |
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