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Comparisons of pathologic findings and outcomes of gastric cancer patients younger and older than 40: a propensity score matching study in a single center of Korea

BACKGROUND AND AIM: Gastric cancer (GC) is one of the most common cancers worldwide, with a high incidence rate in Korean men. However, comparative studies are scarce on the pathologic findings and treatment effects of GC in patients aged less than 40 years. We evaluated the characteristics and path...

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Autores principales: Kim, Yo H, Jung, Yu M, Park, Tae Y, Jeong, Su J, Kim, Tae H, Lee, Jin, Park, Jongha, Kim, Tae O, Park, Yong E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Publishing Asia Pty Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958344/
https://www.ncbi.nlm.nih.gov/pubmed/36852144
http://dx.doi.org/10.1002/jgh3.12860
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author Kim, Yo H
Jung, Yu M
Park, Tae Y
Jeong, Su J
Kim, Tae H
Lee, Jin
Park, Jongha
Kim, Tae O
Park, Yong E
author_facet Kim, Yo H
Jung, Yu M
Park, Tae Y
Jeong, Su J
Kim, Tae H
Lee, Jin
Park, Jongha
Kim, Tae O
Park, Yong E
author_sort Kim, Yo H
collection PubMed
description BACKGROUND AND AIM: Gastric cancer (GC) is one of the most common cancers worldwide, with a high incidence rate in Korean men. However, comparative studies are scarce on the pathologic findings and treatment effects of GC in patients aged less than 40 years. We evaluated the characteristics and pathologic findings of GC patients aged younger and older than 40 years. METHODS: We retrospectively analyzed 2307 patients diagnosed with GC between January 2010 and May 2018. Eighty‐eight (3.8%) and 2219 (96.2%) patients were younger and older than 40 years, respectively. The patients were divided into younger (n = 70) and older (n = 62) age groups through propensity matching. RESULTS: Overall, compared to the younger group, the older group (n = 2219) had a significantly higher proportion of male patients (66.7% vs 39.8%; P < 0.001) and patients who underwent endoscopic submucosal dissection (ESD) (2.3% vs 23.1%; P < 0.001). However, young patients more often underwent operations compared to older patients (78.4% vs 60.1%; P = 0.001). In the propensity‐matched group, older patients more often showed differentiated carcinoma, including well‐differentiated (5.7% vs 11.3%) and moderately differentiated (1.4% vs 32.3%). However, younger patients more often showed signet ring cell carcinoma (SRC) (70.0% vs 25.8%). In multivariate analysis, Helicobacter pylori infection (odds ratio, 12.643; 95% confidence interval, 1.068–1449.665; P = 0.044) independently correlated with SRC risk. CONCLUSIONS: Patients below 40 years were more likely to undergo surgery compared to ESD, and pathologic findings were more common in SRC. Therefore, more active screening and H. pylori eradication are needed even in patients aged less than 40 years.
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spelling pubmed-99583442023-02-26 Comparisons of pathologic findings and outcomes of gastric cancer patients younger and older than 40: a propensity score matching study in a single center of Korea Kim, Yo H Jung, Yu M Park, Tae Y Jeong, Su J Kim, Tae H Lee, Jin Park, Jongha Kim, Tae O Park, Yong E JGH Open Original Articles BACKGROUND AND AIM: Gastric cancer (GC) is one of the most common cancers worldwide, with a high incidence rate in Korean men. However, comparative studies are scarce on the pathologic findings and treatment effects of GC in patients aged less than 40 years. We evaluated the characteristics and pathologic findings of GC patients aged younger and older than 40 years. METHODS: We retrospectively analyzed 2307 patients diagnosed with GC between January 2010 and May 2018. Eighty‐eight (3.8%) and 2219 (96.2%) patients were younger and older than 40 years, respectively. The patients were divided into younger (n = 70) and older (n = 62) age groups through propensity matching. RESULTS: Overall, compared to the younger group, the older group (n = 2219) had a significantly higher proportion of male patients (66.7% vs 39.8%; P < 0.001) and patients who underwent endoscopic submucosal dissection (ESD) (2.3% vs 23.1%; P < 0.001). However, young patients more often underwent operations compared to older patients (78.4% vs 60.1%; P = 0.001). In the propensity‐matched group, older patients more often showed differentiated carcinoma, including well‐differentiated (5.7% vs 11.3%) and moderately differentiated (1.4% vs 32.3%). However, younger patients more often showed signet ring cell carcinoma (SRC) (70.0% vs 25.8%). In multivariate analysis, Helicobacter pylori infection (odds ratio, 12.643; 95% confidence interval, 1.068–1449.665; P = 0.044) independently correlated with SRC risk. CONCLUSIONS: Patients below 40 years were more likely to undergo surgery compared to ESD, and pathologic findings were more common in SRC. Therefore, more active screening and H. pylori eradication are needed even in patients aged less than 40 years. Wiley Publishing Asia Pty Ltd 2023-01-15 /pmc/articles/PMC9958344/ /pubmed/36852144 http://dx.doi.org/10.1002/jgh3.12860 Text en © 2023 The Authors. JGH Open published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Kim, Yo H
Jung, Yu M
Park, Tae Y
Jeong, Su J
Kim, Tae H
Lee, Jin
Park, Jongha
Kim, Tae O
Park, Yong E
Comparisons of pathologic findings and outcomes of gastric cancer patients younger and older than 40: a propensity score matching study in a single center of Korea
title Comparisons of pathologic findings and outcomes of gastric cancer patients younger and older than 40: a propensity score matching study in a single center of Korea
title_full Comparisons of pathologic findings and outcomes of gastric cancer patients younger and older than 40: a propensity score matching study in a single center of Korea
title_fullStr Comparisons of pathologic findings and outcomes of gastric cancer patients younger and older than 40: a propensity score matching study in a single center of Korea
title_full_unstemmed Comparisons of pathologic findings and outcomes of gastric cancer patients younger and older than 40: a propensity score matching study in a single center of Korea
title_short Comparisons of pathologic findings and outcomes of gastric cancer patients younger and older than 40: a propensity score matching study in a single center of Korea
title_sort comparisons of pathologic findings and outcomes of gastric cancer patients younger and older than 40: a propensity score matching study in a single center of korea
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958344/
https://www.ncbi.nlm.nih.gov/pubmed/36852144
http://dx.doi.org/10.1002/jgh3.12860
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