Forced enhancer-promoter rewiring to alter gene expression in animal models

Transcriptional enhancers can be in physical proximity of their target genes via chromatin looping. The enhancer at the β-globin locus (locus control region [LCR]) contacts the fetal-type (HBG) and adult-type (HBB) β-globin genes during corresponding developmental stages. We have demonstrated previo...

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Detalles Bibliográficos
Autores principales: Peslak, Scott A., Demirci, Selami, Chandra, Vemika, Ryu, Byoung, Bhardwaj, Saurabh K., Jiang, Jing, Rupon, Jeremy W., Throm, Robert E., Uchida, Naoya, Leonard, Alexis, Essawi, Khaled, Bonifacino, Aylin C., Krouse, Allen E., Linde, Nathaniel S., Donahue, Robert E., Ferrara, Francesca, Wielgosz, Matthew, Abdulmalik, Osheiza, Hamagami, Nicole, Germino-Watnick, Paula, Le, Anh, Chu, Rebecca, Hinds, Malikiya, Weiss, Mitchell J., Tong, Wei, Tisdale, John F., Blobel, Gerd A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958407/
https://www.ncbi.nlm.nih.gov/pubmed/36852088
http://dx.doi.org/10.1016/j.omtn.2023.01.016

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