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Complex interaction network revealed by mutation of human telomerase ‘insertion in fingers’ and essential N-terminal domains and the telomere protein TPP1
In the majority of human cancer cells, cellular immortalization depends on the maintenance of telomere length by telomerase. An essential step required for telomerase function is its recruitment to telomeres, which is regulated by the interaction of the telomere protein, TPP1, with the telomerase es...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958494/ https://www.ncbi.nlm.nih.gov/pubmed/36649908 http://dx.doi.org/10.1016/j.jbc.2023.102916 |