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Left Ventricular Hypertrophy and Ventricular Tachyarrhythmia: The Role of Biomarkers
Left ventricular hypertrophy (LVH) refers to a complex rebuilding of the left ventricle that can gradually lead to serious complications—heart failure and life-threatening ventricular arrhythmias. LVH is defined as an increase in the size of the left ventricle (i.e., anatomically), therefore the bas...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958550/ https://www.ncbi.nlm.nih.gov/pubmed/36835293 http://dx.doi.org/10.3390/ijms24043881 |
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author | Bacharova, Ljuba Kollarova, Marta Bezak, Branislav Bohm, Allan |
author_facet | Bacharova, Ljuba Kollarova, Marta Bezak, Branislav Bohm, Allan |
author_sort | Bacharova, Ljuba |
collection | PubMed |
description | Left ventricular hypertrophy (LVH) refers to a complex rebuilding of the left ventricle that can gradually lead to serious complications—heart failure and life-threatening ventricular arrhythmias. LVH is defined as an increase in the size of the left ventricle (i.e., anatomically), therefore the basic diagnosis detecting the increase in the LV size is the domain of imaging methods such as echocardiography and cardiac magnetic resonance. However, to evaluate the functional status indicating the gradual deterioration of the left ventricular myocardium, additional methods are available approaching the complex process of hypertrophic remodeling. The novel molecular and genetic biomarkers provide insights on the underlying processes, representing a potential basis for targeted therapy. This review summarizes the spectrum of the main biomarkers employed in the LVH valuation. |
format | Online Article Text |
id | pubmed-9958550 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99585502023-02-26 Left Ventricular Hypertrophy and Ventricular Tachyarrhythmia: The Role of Biomarkers Bacharova, Ljuba Kollarova, Marta Bezak, Branislav Bohm, Allan Int J Mol Sci Review Left ventricular hypertrophy (LVH) refers to a complex rebuilding of the left ventricle that can gradually lead to serious complications—heart failure and life-threatening ventricular arrhythmias. LVH is defined as an increase in the size of the left ventricle (i.e., anatomically), therefore the basic diagnosis detecting the increase in the LV size is the domain of imaging methods such as echocardiography and cardiac magnetic resonance. However, to evaluate the functional status indicating the gradual deterioration of the left ventricular myocardium, additional methods are available approaching the complex process of hypertrophic remodeling. The novel molecular and genetic biomarkers provide insights on the underlying processes, representing a potential basis for targeted therapy. This review summarizes the spectrum of the main biomarkers employed in the LVH valuation. MDPI 2023-02-15 /pmc/articles/PMC9958550/ /pubmed/36835293 http://dx.doi.org/10.3390/ijms24043881 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bacharova, Ljuba Kollarova, Marta Bezak, Branislav Bohm, Allan Left Ventricular Hypertrophy and Ventricular Tachyarrhythmia: The Role of Biomarkers |
title | Left Ventricular Hypertrophy and Ventricular Tachyarrhythmia: The Role of Biomarkers |
title_full | Left Ventricular Hypertrophy and Ventricular Tachyarrhythmia: The Role of Biomarkers |
title_fullStr | Left Ventricular Hypertrophy and Ventricular Tachyarrhythmia: The Role of Biomarkers |
title_full_unstemmed | Left Ventricular Hypertrophy and Ventricular Tachyarrhythmia: The Role of Biomarkers |
title_short | Left Ventricular Hypertrophy and Ventricular Tachyarrhythmia: The Role of Biomarkers |
title_sort | left ventricular hypertrophy and ventricular tachyarrhythmia: the role of biomarkers |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958550/ https://www.ncbi.nlm.nih.gov/pubmed/36835293 http://dx.doi.org/10.3390/ijms24043881 |
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