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Left Ventricular Hypertrophy and Ventricular Tachyarrhythmia: The Role of Biomarkers

Left ventricular hypertrophy (LVH) refers to a complex rebuilding of the left ventricle that can gradually lead to serious complications—heart failure and life-threatening ventricular arrhythmias. LVH is defined as an increase in the size of the left ventricle (i.e., anatomically), therefore the bas...

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Detalles Bibliográficos
Autores principales: Bacharova, Ljuba, Kollarova, Marta, Bezak, Branislav, Bohm, Allan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958550/
https://www.ncbi.nlm.nih.gov/pubmed/36835293
http://dx.doi.org/10.3390/ijms24043881
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author Bacharova, Ljuba
Kollarova, Marta
Bezak, Branislav
Bohm, Allan
author_facet Bacharova, Ljuba
Kollarova, Marta
Bezak, Branislav
Bohm, Allan
author_sort Bacharova, Ljuba
collection PubMed
description Left ventricular hypertrophy (LVH) refers to a complex rebuilding of the left ventricle that can gradually lead to serious complications—heart failure and life-threatening ventricular arrhythmias. LVH is defined as an increase in the size of the left ventricle (i.e., anatomically), therefore the basic diagnosis detecting the increase in the LV size is the domain of imaging methods such as echocardiography and cardiac magnetic resonance. However, to evaluate the functional status indicating the gradual deterioration of the left ventricular myocardium, additional methods are available approaching the complex process of hypertrophic remodeling. The novel molecular and genetic biomarkers provide insights on the underlying processes, representing a potential basis for targeted therapy. This review summarizes the spectrum of the main biomarkers employed in the LVH valuation.
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spelling pubmed-99585502023-02-26 Left Ventricular Hypertrophy and Ventricular Tachyarrhythmia: The Role of Biomarkers Bacharova, Ljuba Kollarova, Marta Bezak, Branislav Bohm, Allan Int J Mol Sci Review Left ventricular hypertrophy (LVH) refers to a complex rebuilding of the left ventricle that can gradually lead to serious complications—heart failure and life-threatening ventricular arrhythmias. LVH is defined as an increase in the size of the left ventricle (i.e., anatomically), therefore the basic diagnosis detecting the increase in the LV size is the domain of imaging methods such as echocardiography and cardiac magnetic resonance. However, to evaluate the functional status indicating the gradual deterioration of the left ventricular myocardium, additional methods are available approaching the complex process of hypertrophic remodeling. The novel molecular and genetic biomarkers provide insights on the underlying processes, representing a potential basis for targeted therapy. This review summarizes the spectrum of the main biomarkers employed in the LVH valuation. MDPI 2023-02-15 /pmc/articles/PMC9958550/ /pubmed/36835293 http://dx.doi.org/10.3390/ijms24043881 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bacharova, Ljuba
Kollarova, Marta
Bezak, Branislav
Bohm, Allan
Left Ventricular Hypertrophy and Ventricular Tachyarrhythmia: The Role of Biomarkers
title Left Ventricular Hypertrophy and Ventricular Tachyarrhythmia: The Role of Biomarkers
title_full Left Ventricular Hypertrophy and Ventricular Tachyarrhythmia: The Role of Biomarkers
title_fullStr Left Ventricular Hypertrophy and Ventricular Tachyarrhythmia: The Role of Biomarkers
title_full_unstemmed Left Ventricular Hypertrophy and Ventricular Tachyarrhythmia: The Role of Biomarkers
title_short Left Ventricular Hypertrophy and Ventricular Tachyarrhythmia: The Role of Biomarkers
title_sort left ventricular hypertrophy and ventricular tachyarrhythmia: the role of biomarkers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958550/
https://www.ncbi.nlm.nih.gov/pubmed/36835293
http://dx.doi.org/10.3390/ijms24043881
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