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Nasal Tumor Vaccination Protects against Lung Tumor Development by Induction of Resident Effector and Memory Anti-Tumor Immune Responses
Lung metastasis is a leading cause of cancer-related deaths. Here, we show that intranasal delivery of our engineered CpG-coated tumor antigen (Tag)-encapsulated nanoparticles (NPs)—nasal nano-vaccine—significantly reduced lung colonization by intravenous challenge of an extra-pulmonary tumor. Prote...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958580/ https://www.ncbi.nlm.nih.gov/pubmed/36839766 http://dx.doi.org/10.3390/pharmaceutics15020445 |
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author | Donkor, Michael Choe, Jamie Reid, Danielle Marie Quinn, Byron Pulse, Mark Ranjan, Amalendu Chaudhary, Pankaj Jones, Harlan P. |
author_facet | Donkor, Michael Choe, Jamie Reid, Danielle Marie Quinn, Byron Pulse, Mark Ranjan, Amalendu Chaudhary, Pankaj Jones, Harlan P. |
author_sort | Donkor, Michael |
collection | PubMed |
description | Lung metastasis is a leading cause of cancer-related deaths. Here, we show that intranasal delivery of our engineered CpG-coated tumor antigen (Tag)-encapsulated nanoparticles (NPs)—nasal nano-vaccine—significantly reduced lung colonization by intravenous challenge of an extra-pulmonary tumor. Protection against tumor-cell lung colonization was linked to the induction of localized mucosal-associated effector and resident memory T cells as well as increased bronchiolar alveolar lavage-fluid IgA and serum IgG antibody responses. The nasal nano-vaccine-induced T-cell-mediated antitumor mucosal immune response was shown to increase tumor-specific production of IFN-γ and granzyme B by lung-derived CD8(+) T cells. These findings demonstrate that our engineered nasal nano-vaccine has the potential to be used as a prophylactic approach prior to the seeding of tumors in the lungs, and thereby prevent overt lung metastases from existing extra pulmonary tumors. |
format | Online Article Text |
id | pubmed-9958580 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99585802023-02-26 Nasal Tumor Vaccination Protects against Lung Tumor Development by Induction of Resident Effector and Memory Anti-Tumor Immune Responses Donkor, Michael Choe, Jamie Reid, Danielle Marie Quinn, Byron Pulse, Mark Ranjan, Amalendu Chaudhary, Pankaj Jones, Harlan P. Pharmaceutics Article Lung metastasis is a leading cause of cancer-related deaths. Here, we show that intranasal delivery of our engineered CpG-coated tumor antigen (Tag)-encapsulated nanoparticles (NPs)—nasal nano-vaccine—significantly reduced lung colonization by intravenous challenge of an extra-pulmonary tumor. Protection against tumor-cell lung colonization was linked to the induction of localized mucosal-associated effector and resident memory T cells as well as increased bronchiolar alveolar lavage-fluid IgA and serum IgG antibody responses. The nasal nano-vaccine-induced T-cell-mediated antitumor mucosal immune response was shown to increase tumor-specific production of IFN-γ and granzyme B by lung-derived CD8(+) T cells. These findings demonstrate that our engineered nasal nano-vaccine has the potential to be used as a prophylactic approach prior to the seeding of tumors in the lungs, and thereby prevent overt lung metastases from existing extra pulmonary tumors. MDPI 2023-01-29 /pmc/articles/PMC9958580/ /pubmed/36839766 http://dx.doi.org/10.3390/pharmaceutics15020445 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Donkor, Michael Choe, Jamie Reid, Danielle Marie Quinn, Byron Pulse, Mark Ranjan, Amalendu Chaudhary, Pankaj Jones, Harlan P. Nasal Tumor Vaccination Protects against Lung Tumor Development by Induction of Resident Effector and Memory Anti-Tumor Immune Responses |
title | Nasal Tumor Vaccination Protects against Lung Tumor Development by Induction of Resident Effector and Memory Anti-Tumor Immune Responses |
title_full | Nasal Tumor Vaccination Protects against Lung Tumor Development by Induction of Resident Effector and Memory Anti-Tumor Immune Responses |
title_fullStr | Nasal Tumor Vaccination Protects against Lung Tumor Development by Induction of Resident Effector and Memory Anti-Tumor Immune Responses |
title_full_unstemmed | Nasal Tumor Vaccination Protects against Lung Tumor Development by Induction of Resident Effector and Memory Anti-Tumor Immune Responses |
title_short | Nasal Tumor Vaccination Protects against Lung Tumor Development by Induction of Resident Effector and Memory Anti-Tumor Immune Responses |
title_sort | nasal tumor vaccination protects against lung tumor development by induction of resident effector and memory anti-tumor immune responses |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958580/ https://www.ncbi.nlm.nih.gov/pubmed/36839766 http://dx.doi.org/10.3390/pharmaceutics15020445 |
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