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Properties and Bioapplications of Amphiphilic Janus Dendrimers: A Review

Amphiphilic Janus dendrimers are arrangements containing both hydrophilic and hydrophobic units, capable of forming ordered aggregates by intermolecular noncovalent interactions between the dendrimer units. Compared to conventional dendrimers, these molecular self-assemblies possess particular and e...

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Detalles Bibliográficos
Autores principales: Căta, Adina, Ienașcu, Ioana Maria Carmen, Ştefănuț, Mariana Nela, Roșu, Dan, Pop, Oana-Raluca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958631/
https://www.ncbi.nlm.nih.gov/pubmed/36839911
http://dx.doi.org/10.3390/pharmaceutics15020589
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author Căta, Adina
Ienașcu, Ioana Maria Carmen
Ştefănuț, Mariana Nela
Roșu, Dan
Pop, Oana-Raluca
author_facet Căta, Adina
Ienașcu, Ioana Maria Carmen
Ştefănuț, Mariana Nela
Roșu, Dan
Pop, Oana-Raluca
author_sort Căta, Adina
collection PubMed
description Amphiphilic Janus dendrimers are arrangements containing both hydrophilic and hydrophobic units, capable of forming ordered aggregates by intermolecular noncovalent interactions between the dendrimer units. Compared to conventional dendrimers, these molecular self-assemblies possess particular and effective attributes i.e., the presence of different terminal groups, essential to design new elaborated materials. The present review will focus on the pharmaceutical and biomedical application of amphiphilic Janus dendrimers. Important information for the development of novel optimized pharmaceutical formulations, such as structural classification, synthetic pathways, properties and applications, will offer the complete characterization of this type of Janus dendrimers. This work will constitute an up-to-date background for dendrimer specialists involved in designing amphiphilic Janus dendrimer-based nanomaterials for future innovations in this promising field.
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spelling pubmed-99586312023-02-26 Properties and Bioapplications of Amphiphilic Janus Dendrimers: A Review Căta, Adina Ienașcu, Ioana Maria Carmen Ştefănuț, Mariana Nela Roșu, Dan Pop, Oana-Raluca Pharmaceutics Review Amphiphilic Janus dendrimers are arrangements containing both hydrophilic and hydrophobic units, capable of forming ordered aggregates by intermolecular noncovalent interactions between the dendrimer units. Compared to conventional dendrimers, these molecular self-assemblies possess particular and effective attributes i.e., the presence of different terminal groups, essential to design new elaborated materials. The present review will focus on the pharmaceutical and biomedical application of amphiphilic Janus dendrimers. Important information for the development of novel optimized pharmaceutical formulations, such as structural classification, synthetic pathways, properties and applications, will offer the complete characterization of this type of Janus dendrimers. This work will constitute an up-to-date background for dendrimer specialists involved in designing amphiphilic Janus dendrimer-based nanomaterials for future innovations in this promising field. MDPI 2023-02-09 /pmc/articles/PMC9958631/ /pubmed/36839911 http://dx.doi.org/10.3390/pharmaceutics15020589 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Căta, Adina
Ienașcu, Ioana Maria Carmen
Ştefănuț, Mariana Nela
Roșu, Dan
Pop, Oana-Raluca
Properties and Bioapplications of Amphiphilic Janus Dendrimers: A Review
title Properties and Bioapplications of Amphiphilic Janus Dendrimers: A Review
title_full Properties and Bioapplications of Amphiphilic Janus Dendrimers: A Review
title_fullStr Properties and Bioapplications of Amphiphilic Janus Dendrimers: A Review
title_full_unstemmed Properties and Bioapplications of Amphiphilic Janus Dendrimers: A Review
title_short Properties and Bioapplications of Amphiphilic Janus Dendrimers: A Review
title_sort properties and bioapplications of amphiphilic janus dendrimers: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958631/
https://www.ncbi.nlm.nih.gov/pubmed/36839911
http://dx.doi.org/10.3390/pharmaceutics15020589
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