Cargando…

Liver-Gut-Interaction: Role of Microbiome Transplantation in the Future Treatment of Metabolic Disease

The association between shifts in gut microbiome composition and metabolic disorders is a well-recognized phenomenon. Clinical studies and experimental data suggest a causal relationship, making the gut microbiome an attractive therapeutic goal. Fecal microbiome transplantation (FMT) is a method to...

Descripción completa

Detalles Bibliográficos
Autor principal: Stadlbauer, Vanessa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958640/
https://www.ncbi.nlm.nih.gov/pubmed/36836454
http://dx.doi.org/10.3390/jpm13020220
_version_ 1784895074232958976
author Stadlbauer, Vanessa
author_facet Stadlbauer, Vanessa
author_sort Stadlbauer, Vanessa
collection PubMed
description The association between shifts in gut microbiome composition and metabolic disorders is a well-recognized phenomenon. Clinical studies and experimental data suggest a causal relationship, making the gut microbiome an attractive therapeutic goal. Fecal microbiome transplantation (FMT) is a method to alter a person’s microbiome composition. Although this method allowed for the establishment of proof of concept for using microbiome modulation to treat metabolic disorders, the method is not yet ready for broad application. It is a resource-intensive method that also carries some procedural risks and whose effects are not always reproducible. This review summarizes the current knowledge on FMT to treat metabolic diseases and gives an outlook on open research questions. Further research is undoubtedly required to find applications that are less resource-intensive, such as oral encapsulated formulations, and have strong and predictable results. Furthermore, a clear commitment from all stakeholders is necessary to move forward in the direction of developing live microbial agents, next-generation probiotics, and targeted dietary interventions.
format Online
Article
Text
id pubmed-9958640
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-99586402023-02-26 Liver-Gut-Interaction: Role of Microbiome Transplantation in the Future Treatment of Metabolic Disease Stadlbauer, Vanessa J Pers Med Perspective The association between shifts in gut microbiome composition and metabolic disorders is a well-recognized phenomenon. Clinical studies and experimental data suggest a causal relationship, making the gut microbiome an attractive therapeutic goal. Fecal microbiome transplantation (FMT) is a method to alter a person’s microbiome composition. Although this method allowed for the establishment of proof of concept for using microbiome modulation to treat metabolic disorders, the method is not yet ready for broad application. It is a resource-intensive method that also carries some procedural risks and whose effects are not always reproducible. This review summarizes the current knowledge on FMT to treat metabolic diseases and gives an outlook on open research questions. Further research is undoubtedly required to find applications that are less resource-intensive, such as oral encapsulated formulations, and have strong and predictable results. Furthermore, a clear commitment from all stakeholders is necessary to move forward in the direction of developing live microbial agents, next-generation probiotics, and targeted dietary interventions. MDPI 2023-01-27 /pmc/articles/PMC9958640/ /pubmed/36836454 http://dx.doi.org/10.3390/jpm13020220 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Stadlbauer, Vanessa
Liver-Gut-Interaction: Role of Microbiome Transplantation in the Future Treatment of Metabolic Disease
title Liver-Gut-Interaction: Role of Microbiome Transplantation in the Future Treatment of Metabolic Disease
title_full Liver-Gut-Interaction: Role of Microbiome Transplantation in the Future Treatment of Metabolic Disease
title_fullStr Liver-Gut-Interaction: Role of Microbiome Transplantation in the Future Treatment of Metabolic Disease
title_full_unstemmed Liver-Gut-Interaction: Role of Microbiome Transplantation in the Future Treatment of Metabolic Disease
title_short Liver-Gut-Interaction: Role of Microbiome Transplantation in the Future Treatment of Metabolic Disease
title_sort liver-gut-interaction: role of microbiome transplantation in the future treatment of metabolic disease
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958640/
https://www.ncbi.nlm.nih.gov/pubmed/36836454
http://dx.doi.org/10.3390/jpm13020220
work_keys_str_mv AT stadlbauervanessa livergutinteractionroleofmicrobiometransplantationinthefuturetreatmentofmetabolicdisease