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Association of 3-Phenoxybenzoic Acid Exposure during Pregnancy with Maternal Outcomes and Newborn Anthropometric Measures: Results from the IoMum Cohort Study

The aims of this study were to characterize the exposure of pregnant women living in Portugal to 3-phenoxybenzoic acid (3-PBA) and to evaluate the association of this exposure with maternal outcomes and newborn anthropometric measures. We also aimed to compare exposure in summer with exposure in win...

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Autores principales: Guimarães, Juliana, Bracchi, Isabella, Pinheiro, Cátia, Moreira, Nara Xavier, Coelho, Cláudia Matta, Pestana, Diogo, Prucha, Maria do Carmo, Martins, Cristina, Domingues, Valentina F., Delerue-Matos, Cristina, Dias, Cláudia C., Azevedo, Luís Filipe R., Calhau, Conceição, Leite, João Costa, Ramalho, Carla, Keating, Elisa, Fernandes, Virgínia Cruz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958656/
https://www.ncbi.nlm.nih.gov/pubmed/36851000
http://dx.doi.org/10.3390/toxics11020125
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author Guimarães, Juliana
Bracchi, Isabella
Pinheiro, Cátia
Moreira, Nara Xavier
Coelho, Cláudia Matta
Pestana, Diogo
Prucha, Maria do Carmo
Martins, Cristina
Domingues, Valentina F.
Delerue-Matos, Cristina
Dias, Cláudia C.
Azevedo, Luís Filipe R.
Calhau, Conceição
Leite, João Costa
Ramalho, Carla
Keating, Elisa
Fernandes, Virgínia Cruz
author_facet Guimarães, Juliana
Bracchi, Isabella
Pinheiro, Cátia
Moreira, Nara Xavier
Coelho, Cláudia Matta
Pestana, Diogo
Prucha, Maria do Carmo
Martins, Cristina
Domingues, Valentina F.
Delerue-Matos, Cristina
Dias, Cláudia C.
Azevedo, Luís Filipe R.
Calhau, Conceição
Leite, João Costa
Ramalho, Carla
Keating, Elisa
Fernandes, Virgínia Cruz
author_sort Guimarães, Juliana
collection PubMed
description The aims of this study were to characterize the exposure of pregnant women living in Portugal to 3-phenoxybenzoic acid (3-PBA) and to evaluate the association of this exposure with maternal outcomes and newborn anthropometric measures. We also aimed to compare exposure in summer with exposure in winter. Pregnant women attending ultrasound scans from April 2018 to April 2019 at a central hospital in Porto, Portugal, were invited to participate. Inclusion criteria were: gestational week between 10 and 13, confirmed fetal vitality, and a signature of informed consent. 3-PBA was measured in spot urine samples by gas chromatography with mass spectrometry (GC-MS). The median 3-PBA concentration was 0.263 (0.167; 0.458) µg/g creatinine (n = 145). 3-PBA excretion was negatively associated with maternal pre-pregnancy body mass index (BMI) (p = 0.049), and it was higher during the summer when compared to winter (p < 0.001). The frequency of fish or yogurt consumption was associated positively with 3-PBA excretion, particularly during the winter (p = 0.002 and p = 0.015, respectively), when environmental exposure is low. Moreover, 3-PBA was associated with levothyroxine use (p = 0.01), a proxy for hypothyroidism, which could be due to a putative 3-PBA—thyroid hormone antagonistic effect. 3-PBA levels were not associated with the anthropometric measures of the newborn. In conclusion, pregnant women living in Portugal are exposed to 3-PBA, particularly during summer, and this exposure may be associated with maternal clinical features.
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spelling pubmed-99586562023-02-26 Association of 3-Phenoxybenzoic Acid Exposure during Pregnancy with Maternal Outcomes and Newborn Anthropometric Measures: Results from the IoMum Cohort Study Guimarães, Juliana Bracchi, Isabella Pinheiro, Cátia Moreira, Nara Xavier Coelho, Cláudia Matta Pestana, Diogo Prucha, Maria do Carmo Martins, Cristina Domingues, Valentina F. Delerue-Matos, Cristina Dias, Cláudia C. Azevedo, Luís Filipe R. Calhau, Conceição Leite, João Costa Ramalho, Carla Keating, Elisa Fernandes, Virgínia Cruz Toxics Article The aims of this study were to characterize the exposure of pregnant women living in Portugal to 3-phenoxybenzoic acid (3-PBA) and to evaluate the association of this exposure with maternal outcomes and newborn anthropometric measures. We also aimed to compare exposure in summer with exposure in winter. Pregnant women attending ultrasound scans from April 2018 to April 2019 at a central hospital in Porto, Portugal, were invited to participate. Inclusion criteria were: gestational week between 10 and 13, confirmed fetal vitality, and a signature of informed consent. 3-PBA was measured in spot urine samples by gas chromatography with mass spectrometry (GC-MS). The median 3-PBA concentration was 0.263 (0.167; 0.458) µg/g creatinine (n = 145). 3-PBA excretion was negatively associated with maternal pre-pregnancy body mass index (BMI) (p = 0.049), and it was higher during the summer when compared to winter (p < 0.001). The frequency of fish or yogurt consumption was associated positively with 3-PBA excretion, particularly during the winter (p = 0.002 and p = 0.015, respectively), when environmental exposure is low. Moreover, 3-PBA was associated with levothyroxine use (p = 0.01), a proxy for hypothyroidism, which could be due to a putative 3-PBA—thyroid hormone antagonistic effect. 3-PBA levels were not associated with the anthropometric measures of the newborn. In conclusion, pregnant women living in Portugal are exposed to 3-PBA, particularly during summer, and this exposure may be associated with maternal clinical features. MDPI 2023-01-27 /pmc/articles/PMC9958656/ /pubmed/36851000 http://dx.doi.org/10.3390/toxics11020125 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Guimarães, Juliana
Bracchi, Isabella
Pinheiro, Cátia
Moreira, Nara Xavier
Coelho, Cláudia Matta
Pestana, Diogo
Prucha, Maria do Carmo
Martins, Cristina
Domingues, Valentina F.
Delerue-Matos, Cristina
Dias, Cláudia C.
Azevedo, Luís Filipe R.
Calhau, Conceição
Leite, João Costa
Ramalho, Carla
Keating, Elisa
Fernandes, Virgínia Cruz
Association of 3-Phenoxybenzoic Acid Exposure during Pregnancy with Maternal Outcomes and Newborn Anthropometric Measures: Results from the IoMum Cohort Study
title Association of 3-Phenoxybenzoic Acid Exposure during Pregnancy with Maternal Outcomes and Newborn Anthropometric Measures: Results from the IoMum Cohort Study
title_full Association of 3-Phenoxybenzoic Acid Exposure during Pregnancy with Maternal Outcomes and Newborn Anthropometric Measures: Results from the IoMum Cohort Study
title_fullStr Association of 3-Phenoxybenzoic Acid Exposure during Pregnancy with Maternal Outcomes and Newborn Anthropometric Measures: Results from the IoMum Cohort Study
title_full_unstemmed Association of 3-Phenoxybenzoic Acid Exposure during Pregnancy with Maternal Outcomes and Newborn Anthropometric Measures: Results from the IoMum Cohort Study
title_short Association of 3-Phenoxybenzoic Acid Exposure during Pregnancy with Maternal Outcomes and Newborn Anthropometric Measures: Results from the IoMum Cohort Study
title_sort association of 3-phenoxybenzoic acid exposure during pregnancy with maternal outcomes and newborn anthropometric measures: results from the iomum cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958656/
https://www.ncbi.nlm.nih.gov/pubmed/36851000
http://dx.doi.org/10.3390/toxics11020125
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