Transmissible Gastroenteritis Virus: An Update Review and Perspective

Transmissible gastroenteritis virus (TGEV) is a member of the alphacoronavirus genus, which has caused huge threats and losses to pig husbandry with a 100% mortality in infected piglets. TGEV is observed to be recombining and evolving unstoppably in recent years, with some of these recombinant strai...

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Autores principales: Chen, Yiwu, Zhang, Yuanzhu, Wang, Xi, Zhou, Jian, Ma, Lerong, Li, Jianing, Yang, Lin, Ouyang, Hongsheng, Yuan, Hongming, Pang, Daxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958687/
https://www.ncbi.nlm.nih.gov/pubmed/36851573
http://dx.doi.org/10.3390/v15020359
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author Chen, Yiwu
Zhang, Yuanzhu
Wang, Xi
Zhou, Jian
Ma, Lerong
Li, Jianing
Yang, Lin
Ouyang, Hongsheng
Yuan, Hongming
Pang, Daxin
author_facet Chen, Yiwu
Zhang, Yuanzhu
Wang, Xi
Zhou, Jian
Ma, Lerong
Li, Jianing
Yang, Lin
Ouyang, Hongsheng
Yuan, Hongming
Pang, Daxin
author_sort Chen, Yiwu
collection PubMed
description Transmissible gastroenteritis virus (TGEV) is a member of the alphacoronavirus genus, which has caused huge threats and losses to pig husbandry with a 100% mortality in infected piglets. TGEV is observed to be recombining and evolving unstoppably in recent years, with some of these recombinant strains spreading across species, which makes the detection and prevention of TGEV more complex. This paper reviews and discusses the basic biological properties of TGEV, factors affecting virulence, viral receptors, and the latest research advances in TGEV infection-induced apoptosis and autophagy to improve understanding of the current status of TGEV and related research processes. We also highlight a possible risk of TGEV being zoonotic, which could be evidenced by the detection of CCoV-HuPn-2018 in humans.
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spelling pubmed-99586872023-02-26 Transmissible Gastroenteritis Virus: An Update Review and Perspective Chen, Yiwu Zhang, Yuanzhu Wang, Xi Zhou, Jian Ma, Lerong Li, Jianing Yang, Lin Ouyang, Hongsheng Yuan, Hongming Pang, Daxin Viruses Review Transmissible gastroenteritis virus (TGEV) is a member of the alphacoronavirus genus, which has caused huge threats and losses to pig husbandry with a 100% mortality in infected piglets. TGEV is observed to be recombining and evolving unstoppably in recent years, with some of these recombinant strains spreading across species, which makes the detection and prevention of TGEV more complex. This paper reviews and discusses the basic biological properties of TGEV, factors affecting virulence, viral receptors, and the latest research advances in TGEV infection-induced apoptosis and autophagy to improve understanding of the current status of TGEV and related research processes. We also highlight a possible risk of TGEV being zoonotic, which could be evidenced by the detection of CCoV-HuPn-2018 in humans. MDPI 2023-01-27 /pmc/articles/PMC9958687/ /pubmed/36851573 http://dx.doi.org/10.3390/v15020359 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chen, Yiwu
Zhang, Yuanzhu
Wang, Xi
Zhou, Jian
Ma, Lerong
Li, Jianing
Yang, Lin
Ouyang, Hongsheng
Yuan, Hongming
Pang, Daxin
Transmissible Gastroenteritis Virus: An Update Review and Perspective
title Transmissible Gastroenteritis Virus: An Update Review and Perspective
title_full Transmissible Gastroenteritis Virus: An Update Review and Perspective
title_fullStr Transmissible Gastroenteritis Virus: An Update Review and Perspective
title_full_unstemmed Transmissible Gastroenteritis Virus: An Update Review and Perspective
title_short Transmissible Gastroenteritis Virus: An Update Review and Perspective
title_sort transmissible gastroenteritis virus: an update review and perspective
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958687/
https://www.ncbi.nlm.nih.gov/pubmed/36851573
http://dx.doi.org/10.3390/v15020359
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