Molecular Mechanisms Responsible for Mesenchymal Stem Cell-Based Modulation of Obstructive Sleep Apnea

Mesenchymal stem cells (MSCs) are adult stem cells that reside in almost all postnatal tissues where, due to the potent regenerative, pro-angiogenic and immunomodulatory properties, regulate tissue homeostasis. Obstructive sleep apnea (OSA) induces oxidative stress, inflammation and ischemia which r...

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Autores principales: Zdravkovic, Marija, Harrell, Carl Randall, Jakovljevic, Vladimir, Djonov, Valentin, Volarevic, Vladislav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958695/
https://www.ncbi.nlm.nih.gov/pubmed/36835120
http://dx.doi.org/10.3390/ijms24043708
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author Zdravkovic, Marija
Harrell, Carl Randall
Jakovljevic, Vladimir
Djonov, Valentin
Volarevic, Vladislav
author_facet Zdravkovic, Marija
Harrell, Carl Randall
Jakovljevic, Vladimir
Djonov, Valentin
Volarevic, Vladislav
author_sort Zdravkovic, Marija
collection PubMed
description Mesenchymal stem cells (MSCs) are adult stem cells that reside in almost all postnatal tissues where, due to the potent regenerative, pro-angiogenic and immunomodulatory properties, regulate tissue homeostasis. Obstructive sleep apnea (OSA) induces oxidative stress, inflammation and ischemia which recruit MSCs from their niches in inflamed and injured tissues. Through the activity of MSC-sourced anti-inflammatory and pro-angiogenic factors, MSCs reduce hypoxia, suppress inflammation, prevent fibrosis and enhance regeneration of damaged cells in OSA-injured tissues. The results obtained in large number of animal studies demonstrated therapeutic efficacy of MSCs in the attenuation of OSA-induced tissue injury and inflammation. Herewith, in this review article, we emphasized molecular mechanisms which are involved in MSC-based neo-vascularization and immunoregulation and we summarized current knowledge about MSC-dependent modulation of OSA-related pathologies.
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spelling pubmed-99586952023-02-26 Molecular Mechanisms Responsible for Mesenchymal Stem Cell-Based Modulation of Obstructive Sleep Apnea Zdravkovic, Marija Harrell, Carl Randall Jakovljevic, Vladimir Djonov, Valentin Volarevic, Vladislav Int J Mol Sci Review Mesenchymal stem cells (MSCs) are adult stem cells that reside in almost all postnatal tissues where, due to the potent regenerative, pro-angiogenic and immunomodulatory properties, regulate tissue homeostasis. Obstructive sleep apnea (OSA) induces oxidative stress, inflammation and ischemia which recruit MSCs from their niches in inflamed and injured tissues. Through the activity of MSC-sourced anti-inflammatory and pro-angiogenic factors, MSCs reduce hypoxia, suppress inflammation, prevent fibrosis and enhance regeneration of damaged cells in OSA-injured tissues. The results obtained in large number of animal studies demonstrated therapeutic efficacy of MSCs in the attenuation of OSA-induced tissue injury and inflammation. Herewith, in this review article, we emphasized molecular mechanisms which are involved in MSC-based neo-vascularization and immunoregulation and we summarized current knowledge about MSC-dependent modulation of OSA-related pathologies. MDPI 2023-02-13 /pmc/articles/PMC9958695/ /pubmed/36835120 http://dx.doi.org/10.3390/ijms24043708 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zdravkovic, Marija
Harrell, Carl Randall
Jakovljevic, Vladimir
Djonov, Valentin
Volarevic, Vladislav
Molecular Mechanisms Responsible for Mesenchymal Stem Cell-Based Modulation of Obstructive Sleep Apnea
title Molecular Mechanisms Responsible for Mesenchymal Stem Cell-Based Modulation of Obstructive Sleep Apnea
title_full Molecular Mechanisms Responsible for Mesenchymal Stem Cell-Based Modulation of Obstructive Sleep Apnea
title_fullStr Molecular Mechanisms Responsible for Mesenchymal Stem Cell-Based Modulation of Obstructive Sleep Apnea
title_full_unstemmed Molecular Mechanisms Responsible for Mesenchymal Stem Cell-Based Modulation of Obstructive Sleep Apnea
title_short Molecular Mechanisms Responsible for Mesenchymal Stem Cell-Based Modulation of Obstructive Sleep Apnea
title_sort molecular mechanisms responsible for mesenchymal stem cell-based modulation of obstructive sleep apnea
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958695/
https://www.ncbi.nlm.nih.gov/pubmed/36835120
http://dx.doi.org/10.3390/ijms24043708
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