Cargando…

Imaging Methods Applicable in the Diagnostics of Alzheimer’s Disease, Considering the Involvement of Insulin Resistance

Alzheimer’s disease (AD) is an incurable neurodegenerative disease and the most frequently diagnosed type of dementia, characterized by (1) perturbed cerebral perfusion, vasculature, and cortical metabolism; (2) induced proinflammatory processes; and (3) the aggregation of amyloid beta and hyperphos...

Descripción completa

Detalles Bibliográficos
Autores principales: Hnilicova, Petra, Kantorova, Ema, Sutovsky, Stanislav, Grofik, Milan, Zelenak, Kamil, Kurca, Egon, Zilka, Norbert, Parvanovova, Petra, Kolisek, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958721/
https://www.ncbi.nlm.nih.gov/pubmed/36834741
http://dx.doi.org/10.3390/ijms24043325
_version_ 1784895094951772160
author Hnilicova, Petra
Kantorova, Ema
Sutovsky, Stanislav
Grofik, Milan
Zelenak, Kamil
Kurca, Egon
Zilka, Norbert
Parvanovova, Petra
Kolisek, Martin
author_facet Hnilicova, Petra
Kantorova, Ema
Sutovsky, Stanislav
Grofik, Milan
Zelenak, Kamil
Kurca, Egon
Zilka, Norbert
Parvanovova, Petra
Kolisek, Martin
author_sort Hnilicova, Petra
collection PubMed
description Alzheimer’s disease (AD) is an incurable neurodegenerative disease and the most frequently diagnosed type of dementia, characterized by (1) perturbed cerebral perfusion, vasculature, and cortical metabolism; (2) induced proinflammatory processes; and (3) the aggregation of amyloid beta and hyperphosphorylated Tau proteins. Subclinical AD changes are commonly detectable by using radiological and nuclear neuroimaging methods such as magnetic resonance imaging (MRI), computed tomography (CT), positron emission tomography (PET), and single-photon emission computed tomography (SPECT). Furthermore, other valuable modalities exist (in particular, structural volumetric, diffusion, perfusion, functional, and metabolic magnetic resonance methods) that can advance the diagnostic algorithm of AD and our understanding of its pathogenesis. Recently, new insights into AD pathoetiology revealed that deranged insulin homeostasis in the brain may play a role in the onset and progression of the disease. AD-related brain insulin resistance is closely linked to systemic insulin homeostasis disorders caused by pancreas and/or liver dysfunction. Indeed, in recent studies, linkages between the development and onset of AD and the liver and/or pancreas have been established. Aside from standard radiological and nuclear neuroimaging methods and clinically fewer common methods of magnetic resonance, this article also discusses the use of new suggestive non-neuronal imaging modalities to assess AD-associated structural changes in the liver and pancreas. Studying these changes might be of great clinical importance because of their possible involvement in AD pathogenesis during the prodromal phase of the disease.
format Online
Article
Text
id pubmed-9958721
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-99587212023-02-26 Imaging Methods Applicable in the Diagnostics of Alzheimer’s Disease, Considering the Involvement of Insulin Resistance Hnilicova, Petra Kantorova, Ema Sutovsky, Stanislav Grofik, Milan Zelenak, Kamil Kurca, Egon Zilka, Norbert Parvanovova, Petra Kolisek, Martin Int J Mol Sci Review Alzheimer’s disease (AD) is an incurable neurodegenerative disease and the most frequently diagnosed type of dementia, characterized by (1) perturbed cerebral perfusion, vasculature, and cortical metabolism; (2) induced proinflammatory processes; and (3) the aggregation of amyloid beta and hyperphosphorylated Tau proteins. Subclinical AD changes are commonly detectable by using radiological and nuclear neuroimaging methods such as magnetic resonance imaging (MRI), computed tomography (CT), positron emission tomography (PET), and single-photon emission computed tomography (SPECT). Furthermore, other valuable modalities exist (in particular, structural volumetric, diffusion, perfusion, functional, and metabolic magnetic resonance methods) that can advance the diagnostic algorithm of AD and our understanding of its pathogenesis. Recently, new insights into AD pathoetiology revealed that deranged insulin homeostasis in the brain may play a role in the onset and progression of the disease. AD-related brain insulin resistance is closely linked to systemic insulin homeostasis disorders caused by pancreas and/or liver dysfunction. Indeed, in recent studies, linkages between the development and onset of AD and the liver and/or pancreas have been established. Aside from standard radiological and nuclear neuroimaging methods and clinically fewer common methods of magnetic resonance, this article also discusses the use of new suggestive non-neuronal imaging modalities to assess AD-associated structural changes in the liver and pancreas. Studying these changes might be of great clinical importance because of their possible involvement in AD pathogenesis during the prodromal phase of the disease. MDPI 2023-02-07 /pmc/articles/PMC9958721/ /pubmed/36834741 http://dx.doi.org/10.3390/ijms24043325 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hnilicova, Petra
Kantorova, Ema
Sutovsky, Stanislav
Grofik, Milan
Zelenak, Kamil
Kurca, Egon
Zilka, Norbert
Parvanovova, Petra
Kolisek, Martin
Imaging Methods Applicable in the Diagnostics of Alzheimer’s Disease, Considering the Involvement of Insulin Resistance
title Imaging Methods Applicable in the Diagnostics of Alzheimer’s Disease, Considering the Involvement of Insulin Resistance
title_full Imaging Methods Applicable in the Diagnostics of Alzheimer’s Disease, Considering the Involvement of Insulin Resistance
title_fullStr Imaging Methods Applicable in the Diagnostics of Alzheimer’s Disease, Considering the Involvement of Insulin Resistance
title_full_unstemmed Imaging Methods Applicable in the Diagnostics of Alzheimer’s Disease, Considering the Involvement of Insulin Resistance
title_short Imaging Methods Applicable in the Diagnostics of Alzheimer’s Disease, Considering the Involvement of Insulin Resistance
title_sort imaging methods applicable in the diagnostics of alzheimer’s disease, considering the involvement of insulin resistance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958721/
https://www.ncbi.nlm.nih.gov/pubmed/36834741
http://dx.doi.org/10.3390/ijms24043325
work_keys_str_mv AT hnilicovapetra imagingmethodsapplicableinthediagnosticsofalzheimersdiseaseconsideringtheinvolvementofinsulinresistance
AT kantorovaema imagingmethodsapplicableinthediagnosticsofalzheimersdiseaseconsideringtheinvolvementofinsulinresistance
AT sutovskystanislav imagingmethodsapplicableinthediagnosticsofalzheimersdiseaseconsideringtheinvolvementofinsulinresistance
AT grofikmilan imagingmethodsapplicableinthediagnosticsofalzheimersdiseaseconsideringtheinvolvementofinsulinresistance
AT zelenakkamil imagingmethodsapplicableinthediagnosticsofalzheimersdiseaseconsideringtheinvolvementofinsulinresistance
AT kurcaegon imagingmethodsapplicableinthediagnosticsofalzheimersdiseaseconsideringtheinvolvementofinsulinresistance
AT zilkanorbert imagingmethodsapplicableinthediagnosticsofalzheimersdiseaseconsideringtheinvolvementofinsulinresistance
AT parvanovovapetra imagingmethodsapplicableinthediagnosticsofalzheimersdiseaseconsideringtheinvolvementofinsulinresistance
AT kolisekmartin imagingmethodsapplicableinthediagnosticsofalzheimersdiseaseconsideringtheinvolvementofinsulinresistance