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Factors Associated with Spontaneous Clearance of Recently Acquired Hepatitis C Virus among HIV-Positive Men in Brazil

Introduction: The objective of the present study was to describe the clinical and epidemiological aspects of recently acquired hepatitis C virus (HCV) infection and the frequency of its spontaneous clearance in a people living with the human immunodeficiency virus (PLWH) cohort. Methods: We reviewed...

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Autores principales: Ferrufino, Rosario Quiroga, Rodrigues, Camila, Figueiredo, Gerusa Maria, Gleison, Daniel, Yapura, Silvia, de Matos, Maria Laura Mariano, Witkin, Steven S., Mendes-Correa, Maria Cássia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958744/
https://www.ncbi.nlm.nih.gov/pubmed/36851529
http://dx.doi.org/10.3390/v15020314
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author Ferrufino, Rosario Quiroga
Rodrigues, Camila
Figueiredo, Gerusa Maria
Gleison, Daniel
Yapura, Silvia
de Matos, Maria Laura Mariano
Witkin, Steven S.
Mendes-Correa, Maria Cássia
author_facet Ferrufino, Rosario Quiroga
Rodrigues, Camila
Figueiredo, Gerusa Maria
Gleison, Daniel
Yapura, Silvia
de Matos, Maria Laura Mariano
Witkin, Steven S.
Mendes-Correa, Maria Cássia
author_sort Ferrufino, Rosario Quiroga
collection PubMed
description Introduction: The objective of the present study was to describe the clinical and epidemiological aspects of recently acquired hepatitis C virus (HCV) infection and the frequency of its spontaneous clearance in a people living with the human immunodeficiency virus (PLWH) cohort. Methods: We reviewed the medical records from all PLWH at the human immunodeficiency virus (HIV) outpatient reference clinic affiliated with the University of São Paulo, Brazil, and identified, by immunoassays and RNA-PCR individuals who acquired HCV infection between January 2015 and December 2017. The factors associated with subsequent spontaneous clearance of the infection in this group were identified and analyzed. Results: Among 3143 PLWH individuals, 362 (11.5%) were coinfected with HCV. Forty-eight (13.2%) of these subjects first became HCV-positive between January 2015 and December 2017. Spontaneous HCV clearance was documented in 23 individuals (47.9%). The majority of this latter group were male (83.3%), and the median age was 31 years (23–39). The main risk group for HCV acquisition was men who had sex with men (MSM) (89.5%). In a multivariate analysis, only an elevated CD4+ T lymphocyte count at the time of seroconversion was found to be associated with subsequent HCV clearance (p = 0.025). Conclusions: In HIV-infected individuals in Sao Paulo, Brazil, most cases of recent HCV transmission were by sexual exposure. In PLWH, particularly in MSM, the individual’s CD4+ T lymphocyte count is a determinant of whether an acquired HCV infection will be prolonged or will spontaneously clear.
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spelling pubmed-99587442023-02-26 Factors Associated with Spontaneous Clearance of Recently Acquired Hepatitis C Virus among HIV-Positive Men in Brazil Ferrufino, Rosario Quiroga Rodrigues, Camila Figueiredo, Gerusa Maria Gleison, Daniel Yapura, Silvia de Matos, Maria Laura Mariano Witkin, Steven S. Mendes-Correa, Maria Cássia Viruses Article Introduction: The objective of the present study was to describe the clinical and epidemiological aspects of recently acquired hepatitis C virus (HCV) infection and the frequency of its spontaneous clearance in a people living with the human immunodeficiency virus (PLWH) cohort. Methods: We reviewed the medical records from all PLWH at the human immunodeficiency virus (HIV) outpatient reference clinic affiliated with the University of São Paulo, Brazil, and identified, by immunoassays and RNA-PCR individuals who acquired HCV infection between January 2015 and December 2017. The factors associated with subsequent spontaneous clearance of the infection in this group were identified and analyzed. Results: Among 3143 PLWH individuals, 362 (11.5%) were coinfected with HCV. Forty-eight (13.2%) of these subjects first became HCV-positive between January 2015 and December 2017. Spontaneous HCV clearance was documented in 23 individuals (47.9%). The majority of this latter group were male (83.3%), and the median age was 31 years (23–39). The main risk group for HCV acquisition was men who had sex with men (MSM) (89.5%). In a multivariate analysis, only an elevated CD4+ T lymphocyte count at the time of seroconversion was found to be associated with subsequent HCV clearance (p = 0.025). Conclusions: In HIV-infected individuals in Sao Paulo, Brazil, most cases of recent HCV transmission were by sexual exposure. In PLWH, particularly in MSM, the individual’s CD4+ T lymphocyte count is a determinant of whether an acquired HCV infection will be prolonged or will spontaneously clear. MDPI 2023-01-23 /pmc/articles/PMC9958744/ /pubmed/36851529 http://dx.doi.org/10.3390/v15020314 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ferrufino, Rosario Quiroga
Rodrigues, Camila
Figueiredo, Gerusa Maria
Gleison, Daniel
Yapura, Silvia
de Matos, Maria Laura Mariano
Witkin, Steven S.
Mendes-Correa, Maria Cássia
Factors Associated with Spontaneous Clearance of Recently Acquired Hepatitis C Virus among HIV-Positive Men in Brazil
title Factors Associated with Spontaneous Clearance of Recently Acquired Hepatitis C Virus among HIV-Positive Men in Brazil
title_full Factors Associated with Spontaneous Clearance of Recently Acquired Hepatitis C Virus among HIV-Positive Men in Brazil
title_fullStr Factors Associated with Spontaneous Clearance of Recently Acquired Hepatitis C Virus among HIV-Positive Men in Brazil
title_full_unstemmed Factors Associated with Spontaneous Clearance of Recently Acquired Hepatitis C Virus among HIV-Positive Men in Brazil
title_short Factors Associated with Spontaneous Clearance of Recently Acquired Hepatitis C Virus among HIV-Positive Men in Brazil
title_sort factors associated with spontaneous clearance of recently acquired hepatitis c virus among hiv-positive men in brazil
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958744/
https://www.ncbi.nlm.nih.gov/pubmed/36851529
http://dx.doi.org/10.3390/v15020314
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