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Subtypes of Adult-Onset Asthma at the Time of Diagnosis: A Latent Class Analysis

Introduction: Only a few previous studies have investigated the subtypes of adult-onset asthma. No previous study has assessed whether these subtypes are different between men and women, or whether these subtypes have different risk factors. Methods: We applied latent class analyses to the Finnish E...

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Autores principales: Mäkikyrö, Elina M. S., Jaakkola, Maritta S., Lajunen, Taina K., Malmberg, L. Pekka, Jaakkola, Jouni J. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958800/
https://www.ncbi.nlm.nih.gov/pubmed/36833767
http://dx.doi.org/10.3390/ijerph20043072
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author Mäkikyrö, Elina M. S.
Jaakkola, Maritta S.
Lajunen, Taina K.
Malmberg, L. Pekka
Jaakkola, Jouni J. K.
author_facet Mäkikyrö, Elina M. S.
Jaakkola, Maritta S.
Lajunen, Taina K.
Malmberg, L. Pekka
Jaakkola, Jouni J. K.
author_sort Mäkikyrö, Elina M. S.
collection PubMed
description Introduction: Only a few previous studies have investigated the subtypes of adult-onset asthma. No previous study has assessed whether these subtypes are different between men and women, or whether these subtypes have different risk factors. Methods: We applied latent class analyses to the Finnish Environment and Asthma Study population, including 520 new cases of adult-onset asthma. We formed subtypes separately between women and men and analyzed the following determinants as potential predictors for these subtypes: age, body mass index, smoking, and parental asthma. Results: Among women, the subtypes identified were: 1. Moderate asthma, 2. Cough-variant asthma, 3. Eosinophilic asthma, 4. Allergic asthma, and 5. Difficult asthma. Among men, the subtypes were: 1. Mild asthma, 2. Moderate asthma, 3. Allergic asthma, and 4. Difficult asthma. Three of the subtypes were similar among women and men: Moderate, Allergic, and Difficult asthma. In addition, women had two distinct subtypes: Cough-variant asthma, and Eosinophilic asthma. These subtypes had different risk factor profiles, e.g., heredity was important for Eosinophilic and Allergic asthma (RR for Both parents having asthma in Eosinophilic 3.55 (1.09 to 11.62)). Furthermore, smoking increased the risk of Moderate asthma among women (RR for former smoking 2.21 (1.19 to 4.11)) and Difficult asthma among men but had little influence on Allergic or Cough-variant asthma. Conclusion: This is an original investigation of the subtypes of adult-onset asthma identified at the time of diagnosis. These subtypes differ between women and men, and these subtypes have different risk factor profiles. These findings have both clinical and public health importance for the etiology, prognosis, and treatment of adult-onset asthma.
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spelling pubmed-99588002023-02-26 Subtypes of Adult-Onset Asthma at the Time of Diagnosis: A Latent Class Analysis Mäkikyrö, Elina M. S. Jaakkola, Maritta S. Lajunen, Taina K. Malmberg, L. Pekka Jaakkola, Jouni J. K. Int J Environ Res Public Health Article Introduction: Only a few previous studies have investigated the subtypes of adult-onset asthma. No previous study has assessed whether these subtypes are different between men and women, or whether these subtypes have different risk factors. Methods: We applied latent class analyses to the Finnish Environment and Asthma Study population, including 520 new cases of adult-onset asthma. We formed subtypes separately between women and men and analyzed the following determinants as potential predictors for these subtypes: age, body mass index, smoking, and parental asthma. Results: Among women, the subtypes identified were: 1. Moderate asthma, 2. Cough-variant asthma, 3. Eosinophilic asthma, 4. Allergic asthma, and 5. Difficult asthma. Among men, the subtypes were: 1. Mild asthma, 2. Moderate asthma, 3. Allergic asthma, and 4. Difficult asthma. Three of the subtypes were similar among women and men: Moderate, Allergic, and Difficult asthma. In addition, women had two distinct subtypes: Cough-variant asthma, and Eosinophilic asthma. These subtypes had different risk factor profiles, e.g., heredity was important for Eosinophilic and Allergic asthma (RR for Both parents having asthma in Eosinophilic 3.55 (1.09 to 11.62)). Furthermore, smoking increased the risk of Moderate asthma among women (RR for former smoking 2.21 (1.19 to 4.11)) and Difficult asthma among men but had little influence on Allergic or Cough-variant asthma. Conclusion: This is an original investigation of the subtypes of adult-onset asthma identified at the time of diagnosis. These subtypes differ between women and men, and these subtypes have different risk factor profiles. These findings have both clinical and public health importance for the etiology, prognosis, and treatment of adult-onset asthma. MDPI 2023-02-09 /pmc/articles/PMC9958800/ /pubmed/36833767 http://dx.doi.org/10.3390/ijerph20043072 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mäkikyrö, Elina M. S.
Jaakkola, Maritta S.
Lajunen, Taina K.
Malmberg, L. Pekka
Jaakkola, Jouni J. K.
Subtypes of Adult-Onset Asthma at the Time of Diagnosis: A Latent Class Analysis
title Subtypes of Adult-Onset Asthma at the Time of Diagnosis: A Latent Class Analysis
title_full Subtypes of Adult-Onset Asthma at the Time of Diagnosis: A Latent Class Analysis
title_fullStr Subtypes of Adult-Onset Asthma at the Time of Diagnosis: A Latent Class Analysis
title_full_unstemmed Subtypes of Adult-Onset Asthma at the Time of Diagnosis: A Latent Class Analysis
title_short Subtypes of Adult-Onset Asthma at the Time of Diagnosis: A Latent Class Analysis
title_sort subtypes of adult-onset asthma at the time of diagnosis: a latent class analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958800/
https://www.ncbi.nlm.nih.gov/pubmed/36833767
http://dx.doi.org/10.3390/ijerph20043072
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