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Compact Modeling of Two-Dimensional Field-Effect Biosensors
A compact model able to predict the electrical read-out of field-effect biosensors based on two-dimensional (2D) semiconductors is introduced. It comprises the analytical description of the electrostatics including the charge density in the 2D semiconductor, the site-binding modeling of the barrier...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958801/ https://www.ncbi.nlm.nih.gov/pubmed/36850440 http://dx.doi.org/10.3390/s23041840 |
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author | Pasadas, Francisco El Grour, Tarek G. Marin, Enrique Medina-Rull, Alberto Toral-Lopez, Alejandro Cuesta-Lopez, Juan G. Ruiz, Francisco El Mir, Lassaad Godoy, Andrés |
author_facet | Pasadas, Francisco El Grour, Tarek G. Marin, Enrique Medina-Rull, Alberto Toral-Lopez, Alejandro Cuesta-Lopez, Juan G. Ruiz, Francisco El Mir, Lassaad Godoy, Andrés |
author_sort | Pasadas, Francisco |
collection | PubMed |
description | A compact model able to predict the electrical read-out of field-effect biosensors based on two-dimensional (2D) semiconductors is introduced. It comprises the analytical description of the electrostatics including the charge density in the 2D semiconductor, the site-binding modeling of the barrier oxide surface charge, and the Stern layer plus an ion-permeable membrane, all coupled with the carrier transport inside the biosensor and solved by making use of the Donnan potential inside the ion-permeable membrane formed by charged macromolecules. This electrostatics and transport description account for the main surface-related physical and chemical processes that impact the biosensor electrical performance, including the transport along the low-dimensional channel in the diffusive regime, electrolyte screening, and the impact of biological charges. The model is implemented in Verilog-A and can be employed on standard circuit design tools. The theoretical predictions obtained with the model are validated against measurements of a MoS(2) field-effect biosensor for streptavidin detection showing excellent agreement in all operation regimes and leading the way for the circuit-level simulation of biosensors based on 2D semiconductors. |
format | Online Article Text |
id | pubmed-9958801 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99588012023-02-26 Compact Modeling of Two-Dimensional Field-Effect Biosensors Pasadas, Francisco El Grour, Tarek G. Marin, Enrique Medina-Rull, Alberto Toral-Lopez, Alejandro Cuesta-Lopez, Juan G. Ruiz, Francisco El Mir, Lassaad Godoy, Andrés Sensors (Basel) Article A compact model able to predict the electrical read-out of field-effect biosensors based on two-dimensional (2D) semiconductors is introduced. It comprises the analytical description of the electrostatics including the charge density in the 2D semiconductor, the site-binding modeling of the barrier oxide surface charge, and the Stern layer plus an ion-permeable membrane, all coupled with the carrier transport inside the biosensor and solved by making use of the Donnan potential inside the ion-permeable membrane formed by charged macromolecules. This electrostatics and transport description account for the main surface-related physical and chemical processes that impact the biosensor electrical performance, including the transport along the low-dimensional channel in the diffusive regime, electrolyte screening, and the impact of biological charges. The model is implemented in Verilog-A and can be employed on standard circuit design tools. The theoretical predictions obtained with the model are validated against measurements of a MoS(2) field-effect biosensor for streptavidin detection showing excellent agreement in all operation regimes and leading the way for the circuit-level simulation of biosensors based on 2D semiconductors. MDPI 2023-02-07 /pmc/articles/PMC9958801/ /pubmed/36850440 http://dx.doi.org/10.3390/s23041840 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pasadas, Francisco El Grour, Tarek G. Marin, Enrique Medina-Rull, Alberto Toral-Lopez, Alejandro Cuesta-Lopez, Juan G. Ruiz, Francisco El Mir, Lassaad Godoy, Andrés Compact Modeling of Two-Dimensional Field-Effect Biosensors |
title | Compact Modeling of Two-Dimensional Field-Effect Biosensors |
title_full | Compact Modeling of Two-Dimensional Field-Effect Biosensors |
title_fullStr | Compact Modeling of Two-Dimensional Field-Effect Biosensors |
title_full_unstemmed | Compact Modeling of Two-Dimensional Field-Effect Biosensors |
title_short | Compact Modeling of Two-Dimensional Field-Effect Biosensors |
title_sort | compact modeling of two-dimensional field-effect biosensors |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958801/ https://www.ncbi.nlm.nih.gov/pubmed/36850440 http://dx.doi.org/10.3390/s23041840 |
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