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Comparison of the Results of Cardiopulmonary Exercise Testing between Healthy Peers and Pediatric Patients with Different Echocardiographic Severity of Mitral Valve Prolapse

Patients with mitral valve prolapse (MVP) have been reported to have exercise intolerance. However, the underlying pathophysiological mechanisms and their physical fitness remain unclear. We aimed to determine the exercise capacity of patients with MVP through the cardiopulmonary exercise test (CPET...

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Autores principales: Huang, Ming-Hsuan, Tuan, Sheng-Hui, Tsai, Yun-Jeng, Huang, Wei-Chun, Huang, Ta-Cheng, Chang, Shin-Tsu, Lin, Ko-Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958875/
https://www.ncbi.nlm.nih.gov/pubmed/36836660
http://dx.doi.org/10.3390/life13020302
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author Huang, Ming-Hsuan
Tuan, Sheng-Hui
Tsai, Yun-Jeng
Huang, Wei-Chun
Huang, Ta-Cheng
Chang, Shin-Tsu
Lin, Ko-Long
author_facet Huang, Ming-Hsuan
Tuan, Sheng-Hui
Tsai, Yun-Jeng
Huang, Wei-Chun
Huang, Ta-Cheng
Chang, Shin-Tsu
Lin, Ko-Long
author_sort Huang, Ming-Hsuan
collection PubMed
description Patients with mitral valve prolapse (MVP) have been reported to have exercise intolerance. However, the underlying pathophysiological mechanisms and their physical fitness remain unclear. We aimed to determine the exercise capacity of patients with MVP through the cardiopulmonary exercise test (CPET). We retrospectively collected the data of 45 patients with a diagnosis of MVP. Their CPET and echocardiogram results were compared with 76 healthy individuals as primary outcomes. No significant differences regarding the patient’s baseline characteristics and echocardiographic data were found between the two groups, except for the lower body mass index (BMI) of the MVP group. Patients in the MVP group demonstrated a similar peak metabolic equivalent (MET), but a significantly lower peak rate pressure product (PRPP) (p = 0.048). Patients with MVP possessed similar exercise capacity to healthy individuals. The reduced PRPP may indicate compromised coronary perfusion and subtle left ventricular function impairment.
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spelling pubmed-99588752023-02-26 Comparison of the Results of Cardiopulmonary Exercise Testing between Healthy Peers and Pediatric Patients with Different Echocardiographic Severity of Mitral Valve Prolapse Huang, Ming-Hsuan Tuan, Sheng-Hui Tsai, Yun-Jeng Huang, Wei-Chun Huang, Ta-Cheng Chang, Shin-Tsu Lin, Ko-Long Life (Basel) Article Patients with mitral valve prolapse (MVP) have been reported to have exercise intolerance. However, the underlying pathophysiological mechanisms and their physical fitness remain unclear. We aimed to determine the exercise capacity of patients with MVP through the cardiopulmonary exercise test (CPET). We retrospectively collected the data of 45 patients with a diagnosis of MVP. Their CPET and echocardiogram results were compared with 76 healthy individuals as primary outcomes. No significant differences regarding the patient’s baseline characteristics and echocardiographic data were found between the two groups, except for the lower body mass index (BMI) of the MVP group. Patients in the MVP group demonstrated a similar peak metabolic equivalent (MET), but a significantly lower peak rate pressure product (PRPP) (p = 0.048). Patients with MVP possessed similar exercise capacity to healthy individuals. The reduced PRPP may indicate compromised coronary perfusion and subtle left ventricular function impairment. MDPI 2023-01-21 /pmc/articles/PMC9958875/ /pubmed/36836660 http://dx.doi.org/10.3390/life13020302 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Ming-Hsuan
Tuan, Sheng-Hui
Tsai, Yun-Jeng
Huang, Wei-Chun
Huang, Ta-Cheng
Chang, Shin-Tsu
Lin, Ko-Long
Comparison of the Results of Cardiopulmonary Exercise Testing between Healthy Peers and Pediatric Patients with Different Echocardiographic Severity of Mitral Valve Prolapse
title Comparison of the Results of Cardiopulmonary Exercise Testing between Healthy Peers and Pediatric Patients with Different Echocardiographic Severity of Mitral Valve Prolapse
title_full Comparison of the Results of Cardiopulmonary Exercise Testing between Healthy Peers and Pediatric Patients with Different Echocardiographic Severity of Mitral Valve Prolapse
title_fullStr Comparison of the Results of Cardiopulmonary Exercise Testing between Healthy Peers and Pediatric Patients with Different Echocardiographic Severity of Mitral Valve Prolapse
title_full_unstemmed Comparison of the Results of Cardiopulmonary Exercise Testing between Healthy Peers and Pediatric Patients with Different Echocardiographic Severity of Mitral Valve Prolapse
title_short Comparison of the Results of Cardiopulmonary Exercise Testing between Healthy Peers and Pediatric Patients with Different Echocardiographic Severity of Mitral Valve Prolapse
title_sort comparison of the results of cardiopulmonary exercise testing between healthy peers and pediatric patients with different echocardiographic severity of mitral valve prolapse
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958875/
https://www.ncbi.nlm.nih.gov/pubmed/36836660
http://dx.doi.org/10.3390/life13020302
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