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Biochemical Association of MTHFR C677T Polymorphism with Myocardial Infarction in the Presence of Diabetes Mellitus as a Risk Factor

Myocardial infarction (MI) is a cardiovascular disease that occurs due to the blockage of the coronary artery. Subsequently, cardiac muscles receive a lower oxygen supply, which leads to the death of cardiac muscles. The etiology of MI is linked to various environmental, occupational, and genetic fa...

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Autores principales: Mallhi, Tauqeer Hussain, Shahid, Momina, Rehman, Kanwal, Khan, Yusra Habib, Alanazi, Abdullah Salah, Alotaibi, Nasser Hadal, Akash, Muhammad Sajid Hamid, Butt, Muhammad Hammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958922/
https://www.ncbi.nlm.nih.gov/pubmed/36837870
http://dx.doi.org/10.3390/metabo13020251
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author Mallhi, Tauqeer Hussain
Shahid, Momina
Rehman, Kanwal
Khan, Yusra Habib
Alanazi, Abdullah Salah
Alotaibi, Nasser Hadal
Akash, Muhammad Sajid Hamid
Butt, Muhammad Hammad
author_facet Mallhi, Tauqeer Hussain
Shahid, Momina
Rehman, Kanwal
Khan, Yusra Habib
Alanazi, Abdullah Salah
Alotaibi, Nasser Hadal
Akash, Muhammad Sajid Hamid
Butt, Muhammad Hammad
author_sort Mallhi, Tauqeer Hussain
collection PubMed
description Myocardial infarction (MI) is a cardiovascular disease that occurs due to the blockage of the coronary artery. Subsequently, cardiac muscles receive a lower oxygen supply, which leads to the death of cardiac muscles. The etiology of MI is linked to various environmental, occupational, and genetic factors. Various studies have been conducted on the polymorphism of genes involved in MI. Previous studies have shown that different variants of the methylene tetrahydrofolate reductase (MTHFR) gene are involved in causing MI by altering the metabolism of folate and homocysteine. However, the genetic polymorphism of MTHFR C677T (rs1801133) and its association with MI in the presence of diabetes mellitus (DM) as a risk factor still needs to be investigated. This study recruited 300 participants who were divided into three groups, i.e., the control, MI, and MI-DM. The blood samples collected from the study participants were subjected to various biochemical tests and their clinical parameters were monitored. MTHFR C677T (rs1801133) genotyping was performed by Tetra ARMS PCR using predetermined primers. The MTHFR C677T (rs1801133) polymorphism was associated with MI in the presence of DM as a risk factor among the participants. The MTHFR C677T (rs1801133) T/T homozygous genotype was found to be significant among MI patients in the presence of DM as a risk factor.
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spelling pubmed-99589222023-02-26 Biochemical Association of MTHFR C677T Polymorphism with Myocardial Infarction in the Presence of Diabetes Mellitus as a Risk Factor Mallhi, Tauqeer Hussain Shahid, Momina Rehman, Kanwal Khan, Yusra Habib Alanazi, Abdullah Salah Alotaibi, Nasser Hadal Akash, Muhammad Sajid Hamid Butt, Muhammad Hammad Metabolites Article Myocardial infarction (MI) is a cardiovascular disease that occurs due to the blockage of the coronary artery. Subsequently, cardiac muscles receive a lower oxygen supply, which leads to the death of cardiac muscles. The etiology of MI is linked to various environmental, occupational, and genetic factors. Various studies have been conducted on the polymorphism of genes involved in MI. Previous studies have shown that different variants of the methylene tetrahydrofolate reductase (MTHFR) gene are involved in causing MI by altering the metabolism of folate and homocysteine. However, the genetic polymorphism of MTHFR C677T (rs1801133) and its association with MI in the presence of diabetes mellitus (DM) as a risk factor still needs to be investigated. This study recruited 300 participants who were divided into three groups, i.e., the control, MI, and MI-DM. The blood samples collected from the study participants were subjected to various biochemical tests and their clinical parameters were monitored. MTHFR C677T (rs1801133) genotyping was performed by Tetra ARMS PCR using predetermined primers. The MTHFR C677T (rs1801133) polymorphism was associated with MI in the presence of DM as a risk factor among the participants. The MTHFR C677T (rs1801133) T/T homozygous genotype was found to be significant among MI patients in the presence of DM as a risk factor. MDPI 2023-02-09 /pmc/articles/PMC9958922/ /pubmed/36837870 http://dx.doi.org/10.3390/metabo13020251 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mallhi, Tauqeer Hussain
Shahid, Momina
Rehman, Kanwal
Khan, Yusra Habib
Alanazi, Abdullah Salah
Alotaibi, Nasser Hadal
Akash, Muhammad Sajid Hamid
Butt, Muhammad Hammad
Biochemical Association of MTHFR C677T Polymorphism with Myocardial Infarction in the Presence of Diabetes Mellitus as a Risk Factor
title Biochemical Association of MTHFR C677T Polymorphism with Myocardial Infarction in the Presence of Diabetes Mellitus as a Risk Factor
title_full Biochemical Association of MTHFR C677T Polymorphism with Myocardial Infarction in the Presence of Diabetes Mellitus as a Risk Factor
title_fullStr Biochemical Association of MTHFR C677T Polymorphism with Myocardial Infarction in the Presence of Diabetes Mellitus as a Risk Factor
title_full_unstemmed Biochemical Association of MTHFR C677T Polymorphism with Myocardial Infarction in the Presence of Diabetes Mellitus as a Risk Factor
title_short Biochemical Association of MTHFR C677T Polymorphism with Myocardial Infarction in the Presence of Diabetes Mellitus as a Risk Factor
title_sort biochemical association of mthfr c677t polymorphism with myocardial infarction in the presence of diabetes mellitus as a risk factor
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958922/
https://www.ncbi.nlm.nih.gov/pubmed/36837870
http://dx.doi.org/10.3390/metabo13020251
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