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Two Years’ Experience of Intensive Home Hemodialysis with the Physidia S(3) System: Results from the RECAP Study

The RECAP study reports results and outcomes (clinical performances, patient acceptance, cardiac outcomes, and technical survival) achieved with the S(3) system used as an intensive home hemodialysis (HHD) platform over a three-year French multicenter study. Ninety-four dialysis patients issued from...

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Autores principales: Fessi, Hafedh, Nicoud, Philippe, Serrato, Tomas, Gilbert, Olivia, Courivaud, Cécile, Daoud, Salima, Morena, Marion, Thomas, Michel, Canaud, Bernard, Cristol, Jean-Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958970/
https://www.ncbi.nlm.nih.gov/pubmed/36835894
http://dx.doi.org/10.3390/jcm12041357
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author Fessi, Hafedh
Nicoud, Philippe
Serrato, Tomas
Gilbert, Olivia
Courivaud, Cécile
Daoud, Salima
Morena, Marion
Thomas, Michel
Canaud, Bernard
Cristol, Jean-Paul
author_facet Fessi, Hafedh
Nicoud, Philippe
Serrato, Tomas
Gilbert, Olivia
Courivaud, Cécile
Daoud, Salima
Morena, Marion
Thomas, Michel
Canaud, Bernard
Cristol, Jean-Paul
author_sort Fessi, Hafedh
collection PubMed
description The RECAP study reports results and outcomes (clinical performances, patient acceptance, cardiac outcomes, and technical survival) achieved with the S(3) system used as an intensive home hemodialysis (HHD) platform over a three-year French multicenter study. Ninety-four dialysis patients issued from ten dialysis centers and treated more than 6 months (mean follow-up: 24 months) with S(3) were included. A two-hour treatment time was maintained in 2/3 of patients to deliver 25 L of dialysis fluid, while 1/3 required up to 3 h to achieve 30 L. The additional convection volume produced by means of the SeCoHD tool (internal filtration backfiltration) was 3 L/session, and the net ultrafiltration produced to achieve dry weight was 1.4 L/session. On a weekly basis, an average 156 L of dialysate corresponding to 94 L of urea clearance when considering 85% dialysate saturation under low flow conditions was delivered. Such urea clearance was equivalent to 9.2 [8.0–13.0] mL/min weekly urea clearance and a standardized Kt/V of 2.5 [1.1–4.5]. The predialysis concentration of selected uremic markers remained remarkably stable over time. Fluid volume status and blood pressure were adequately controlled by means of a relatively low ultrafiltration rate (7.9 mL/h/kg). Technical survival on S(3) was 72% and 58% at 1 and 2 years, respectively. The S(3) system was easily handled and kept by patients at home, as indicated by technical survival. Patient perception was improved, while treatment burden was reduced. Cardiac features (assessed in a subset of patients) tended to improve over time. Intensive hemodialysis relying on the S(3) system offers a very appealing option for home treatment with quite satisfactory results, as shown in the RECAP study throughout a two-year follow-up time, and offers the best bridging solution to kidney transplantation.
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spelling pubmed-99589702023-02-26 Two Years’ Experience of Intensive Home Hemodialysis with the Physidia S(3) System: Results from the RECAP Study Fessi, Hafedh Nicoud, Philippe Serrato, Tomas Gilbert, Olivia Courivaud, Cécile Daoud, Salima Morena, Marion Thomas, Michel Canaud, Bernard Cristol, Jean-Paul J Clin Med Article The RECAP study reports results and outcomes (clinical performances, patient acceptance, cardiac outcomes, and technical survival) achieved with the S(3) system used as an intensive home hemodialysis (HHD) platform over a three-year French multicenter study. Ninety-four dialysis patients issued from ten dialysis centers and treated more than 6 months (mean follow-up: 24 months) with S(3) were included. A two-hour treatment time was maintained in 2/3 of patients to deliver 25 L of dialysis fluid, while 1/3 required up to 3 h to achieve 30 L. The additional convection volume produced by means of the SeCoHD tool (internal filtration backfiltration) was 3 L/session, and the net ultrafiltration produced to achieve dry weight was 1.4 L/session. On a weekly basis, an average 156 L of dialysate corresponding to 94 L of urea clearance when considering 85% dialysate saturation under low flow conditions was delivered. Such urea clearance was equivalent to 9.2 [8.0–13.0] mL/min weekly urea clearance and a standardized Kt/V of 2.5 [1.1–4.5]. The predialysis concentration of selected uremic markers remained remarkably stable over time. Fluid volume status and blood pressure were adequately controlled by means of a relatively low ultrafiltration rate (7.9 mL/h/kg). Technical survival on S(3) was 72% and 58% at 1 and 2 years, respectively. The S(3) system was easily handled and kept by patients at home, as indicated by technical survival. Patient perception was improved, while treatment burden was reduced. Cardiac features (assessed in a subset of patients) tended to improve over time. Intensive hemodialysis relying on the S(3) system offers a very appealing option for home treatment with quite satisfactory results, as shown in the RECAP study throughout a two-year follow-up time, and offers the best bridging solution to kidney transplantation. MDPI 2023-02-08 /pmc/articles/PMC9958970/ /pubmed/36835894 http://dx.doi.org/10.3390/jcm12041357 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fessi, Hafedh
Nicoud, Philippe
Serrato, Tomas
Gilbert, Olivia
Courivaud, Cécile
Daoud, Salima
Morena, Marion
Thomas, Michel
Canaud, Bernard
Cristol, Jean-Paul
Two Years’ Experience of Intensive Home Hemodialysis with the Physidia S(3) System: Results from the RECAP Study
title Two Years’ Experience of Intensive Home Hemodialysis with the Physidia S(3) System: Results from the RECAP Study
title_full Two Years’ Experience of Intensive Home Hemodialysis with the Physidia S(3) System: Results from the RECAP Study
title_fullStr Two Years’ Experience of Intensive Home Hemodialysis with the Physidia S(3) System: Results from the RECAP Study
title_full_unstemmed Two Years’ Experience of Intensive Home Hemodialysis with the Physidia S(3) System: Results from the RECAP Study
title_short Two Years’ Experience of Intensive Home Hemodialysis with the Physidia S(3) System: Results from the RECAP Study
title_sort two years’ experience of intensive home hemodialysis with the physidia s(3) system: results from the recap study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958970/
https://www.ncbi.nlm.nih.gov/pubmed/36835894
http://dx.doi.org/10.3390/jcm12041357
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