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Updated Views in Targeted Therapy in the Patient with Non-Small Cell Lung Cancer
Non-small cell lung cancer (NSCLC) is the most frequent form of lung cancer and represents a set of histological entities that have an ominous long-term prognosis, for example, adenocarcinoma, squamous carcinoma and large cell carcinoma. Both small cell and non-small cell lung cancer are the main ca...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959016/ https://www.ncbi.nlm.nih.gov/pubmed/36836402 http://dx.doi.org/10.3390/jpm13020167 |
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author | Ortega, Miguel A. Pekarek, Leonel Navarro, Fátima Fraile-Martínez, Oscar García-Montero, Cielo Álvarez-Mon, Miguel Ángel Diez-Pedrero, Raúl Boyano-Adánez, María del Carmen Guijarro, Luis G. Barrena-Blázquez, Silvestra Gómez-Lahoz, Ana M. Haro, Sergio Arroyo, Mónica Monserrat, Jorge Saez, Miguel A. Alvarez-Mon, Melchor |
author_facet | Ortega, Miguel A. Pekarek, Leonel Navarro, Fátima Fraile-Martínez, Oscar García-Montero, Cielo Álvarez-Mon, Miguel Ángel Diez-Pedrero, Raúl Boyano-Adánez, María del Carmen Guijarro, Luis G. Barrena-Blázquez, Silvestra Gómez-Lahoz, Ana M. Haro, Sergio Arroyo, Mónica Monserrat, Jorge Saez, Miguel A. Alvarez-Mon, Melchor |
author_sort | Ortega, Miguel A. |
collection | PubMed |
description | Non-small cell lung cancer (NSCLC) is the most frequent form of lung cancer and represents a set of histological entities that have an ominous long-term prognosis, for example, adenocarcinoma, squamous carcinoma and large cell carcinoma. Both small cell and non-small cell lung cancer are the main causes of oncological death and the oncological diseases with the highest incidence worldwide. With regard to clinical approaches for NSCLC, several advances have been achieved in diagnosis and treatment; the analysis of different molecular markers has led to the development of new targeted therapies that have improved the prognosis for selected patients. Despite this, most patients are diagnosed in an advanced stage, presenting a limited life expectancy with an ominous short-term prognosis. Numerous molecular alterations have been described in recent years, allowing for the development of therapies directed against specific therapeutic targets. The correct identification of the expression of different molecular markers has allowed for the individualization of treatment throughout the disease course, expanding the available therapeutic arsenal. The purpose of this article is to summarize the main characteristics of NSCLC and the advances that have occurred in the use of targeted therapies, thus explaining the limitations that have been observed in the management of this disease. |
format | Online Article Text |
id | pubmed-9959016 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99590162023-02-26 Updated Views in Targeted Therapy in the Patient with Non-Small Cell Lung Cancer Ortega, Miguel A. Pekarek, Leonel Navarro, Fátima Fraile-Martínez, Oscar García-Montero, Cielo Álvarez-Mon, Miguel Ángel Diez-Pedrero, Raúl Boyano-Adánez, María del Carmen Guijarro, Luis G. Barrena-Blázquez, Silvestra Gómez-Lahoz, Ana M. Haro, Sergio Arroyo, Mónica Monserrat, Jorge Saez, Miguel A. Alvarez-Mon, Melchor J Pers Med Review Non-small cell lung cancer (NSCLC) is the most frequent form of lung cancer and represents a set of histological entities that have an ominous long-term prognosis, for example, adenocarcinoma, squamous carcinoma and large cell carcinoma. Both small cell and non-small cell lung cancer are the main causes of oncological death and the oncological diseases with the highest incidence worldwide. With regard to clinical approaches for NSCLC, several advances have been achieved in diagnosis and treatment; the analysis of different molecular markers has led to the development of new targeted therapies that have improved the prognosis for selected patients. Despite this, most patients are diagnosed in an advanced stage, presenting a limited life expectancy with an ominous short-term prognosis. Numerous molecular alterations have been described in recent years, allowing for the development of therapies directed against specific therapeutic targets. The correct identification of the expression of different molecular markers has allowed for the individualization of treatment throughout the disease course, expanding the available therapeutic arsenal. The purpose of this article is to summarize the main characteristics of NSCLC and the advances that have occurred in the use of targeted therapies, thus explaining the limitations that have been observed in the management of this disease. MDPI 2023-01-17 /pmc/articles/PMC9959016/ /pubmed/36836402 http://dx.doi.org/10.3390/jpm13020167 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ortega, Miguel A. Pekarek, Leonel Navarro, Fátima Fraile-Martínez, Oscar García-Montero, Cielo Álvarez-Mon, Miguel Ángel Diez-Pedrero, Raúl Boyano-Adánez, María del Carmen Guijarro, Luis G. Barrena-Blázquez, Silvestra Gómez-Lahoz, Ana M. Haro, Sergio Arroyo, Mónica Monserrat, Jorge Saez, Miguel A. Alvarez-Mon, Melchor Updated Views in Targeted Therapy in the Patient with Non-Small Cell Lung Cancer |
title | Updated Views in Targeted Therapy in the Patient with Non-Small Cell Lung Cancer |
title_full | Updated Views in Targeted Therapy in the Patient with Non-Small Cell Lung Cancer |
title_fullStr | Updated Views in Targeted Therapy in the Patient with Non-Small Cell Lung Cancer |
title_full_unstemmed | Updated Views in Targeted Therapy in the Patient with Non-Small Cell Lung Cancer |
title_short | Updated Views in Targeted Therapy in the Patient with Non-Small Cell Lung Cancer |
title_sort | updated views in targeted therapy in the patient with non-small cell lung cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959016/ https://www.ncbi.nlm.nih.gov/pubmed/36836402 http://dx.doi.org/10.3390/jpm13020167 |
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